Environment and Breast Cancer: Science Review
AboutCancer studies: Mammary gland tumors
Originating list
The list(s) or database(s) in which the chemical was identified as showing an
increase in mammary gland tumors. CPDB: Carcinogenic Potency Database, IARC:
International Agency for Research on Chemicals Monographs on the Evaluation of
Carcinogenic Risk of Chemicals to Man summaries, NTP TR: National Toxicology Program
(NTP) Technical Reports, NTP 11ROC: NTP 11th Report on Carcinogens, CCRIS: Chemical
Carcinogenesis Research Information Service.
National Toxicology Program studies, Chemical Carcinogenesis Research Information System
Mammary gland tumor summary
A summary of findings related to mammary gland tumors, most
often excerpted from IARC Monographs or the NTP 11th ROC, and, in some cases,
supplemented by our evaluation of individual studies and reviews, is available for the priority
chemicals and 67 others.
Snedeker, 1999: Most studies done in experimental animals are invalid as cancer bioassays by contemporary standards. One study that used sufficient exposure time and large number of animals (Chan et al.,1991), reported an increase in incidence of mammary gland fibroadenomas/adenomas (benign) in one of the two groups of female F344 rats that were fed dichlorvos.
Citations to review sources and individual studies reporting mammary gland tumors are listed below.
Citation
Source Type
Notes
International Agency for Research on Cancer, Monographs on the evaluation of carcinogenic risk of chemicals to man.VOL.: 53 (1991) (p. 267) Dichlorvos.
Review
Carcinogenic Potency Database 2005. Gold LS ST, Manley NB, Garfinkel GB, Ames BN. Summary Table by Chemical of Carcinogenicity Results in CPDB on 1485 Chemicals. 2005
Review
Blair D, Dix KM, Hunt PF, Thorpe E, Stevenson DE, Walker AI. Dichlorvos -- a 2-year inhalation carcinogenesis study in rats. Arch Toxicol 1976;35(4):281-94.
Primary Literature
Chan, P. C., Huff, J., Haseman, J. K., Alison, R., and Prejean, J. D. (1991). Carcinogenesis studies of dichlorvos in Fischer rats and B6C3F1 mice. Japanese Journal of Cancer Research 82, 157-164.
Primary Literature
National Toxicology Program Technical Report 342, 1989
Primary Literature
National Toxicology Program Technical Report 342, 1989
Primary Literature
Snedeker, S. M., Clark, H. "Critical Evaluation of Atrazine's Breast Cancer Risk," Cornell University, 1999.
Primary Literature
National Toxicology Program 11th Report on Carcinogens, Table 1. Chemicals nominated to the National Toxicology Program for in-depth toxicological evaluation for carcinogenesis testing in fiscal years 1988-2003.
Review