Environment and Breast Cancer: Science Review
Major use
We assigned each chemical into one of the following groups based on its major
sources and uses: industrial chemicals, chlorinated solvents, products of combustion,
pesticides, dyes, radiation and drinking water disinfection, pharmaceuticals, hormones, natural
products, and research chemicals.
Pesticide
Found in consumer products
"Likely" indicates that the chemical is contained in consumer
products or traces of the chemical are present in products, including food and water, resulting
in likely exposure for the general population. For some chemicals marked as "likely," consumer
product uses have been discontinued, and this will be indicated in the "Use in Consumer
Products" field.
Likely
Food additive in US
Chemicals are classified as "Listed" or "Not listed" in the Everything
Added to Food in the United States database developed by the US Food and Drug
Administration.(22)
Not listed
California Proposition 65
Chemicals are labeled "Listed" or "Not listed" based on the Proposition 65 list of chemicals updated on May 27, 2005. Listed chemicals are "chemicals known by the State of
California to cause cancer or reproductive toxicity"(19).
Listed
Air pollutant
Chemicals classified as "Likely" air pollutants are those likely to be found in
indoor or outdoor air, including products of combustion and industrial chemicals that may offgas
from consumer products, leading to human exposure.
Likely
Current High Production Volume chemical
Chemicals are classified "Yes" or "No," based on
2002 production volume information submitted to the US EPA: "Yes" for >1 million pounds
produced; "No" for < 1 million pounds produced. Some past production volumes are
referenced, where appropriate, in the HPV comment column (20). In addition, Scorecard.org is
referenced and noted in the HPV comment column when it was inconsistent with current
production volume information obtained from US EPA (21).
No
High Production Volume comment
Chemicals are classified "Yes" or "No," based on
2002 production volume information submitted to the US EPA: "Yes" for >1 million pounds
produced; "No" for < 1 million pounds produced. Some past production volumes are
referenced, where appropriate, in the HPV comment column (20). In addition, Scorecard.org is
referenced and noted in the HPV comment column when it was inconsistent with current
production volume information obtained from US EPA (21).
(Produced in 10K - 500K (1998), >500K - 1M (1990), and >1M - 10M (1994,1986) range in the past) Yes (scorecard.org)
Production volume information
Production volume information is from the US EPA database
on non-confidential production volume information submitted by companies for chemicals
under the 1986-2002 Inventory Update Rule (IUR) using the most updated (2002) values (20).
The Inventory Update Rule requires the submission of basic production data every four years
on chemical substances manufactured (including imported) for commercial purposes in
amounts of 25,000 pounds or more at a single site. Out of over 80,000 chemicals on the TSCA
Chemical Substances Inventory, reports are required for approximately 9,000 substances. For
those substances with annual volumes of 300,000 lbs or more per site, reporters also submit
chemical processing and use information.
No Reports
General population exposure
This field includes information describing pathways of exposure
for the general population obtained from a variety of sources including: IARC Monographs (9),
NTP 11th ROC on Carcinogens (4), NTP Study Reports and Abstracts (3), Hazardous Substance
Database (10), and other sources located through use of the Google search engine.
Household and public health uses represent the main sources of human exposure (IARC 1991 vol.:53 p.267). The general population may be exposed via inhalation of air and dermal contact when no-pest strips, sprays or flea collars containing this insecticide are used. Exposure could also result from ingestion of food which has been prepared in rooms where dichlorvos is used for insect control (HSDB).
Use in consumer products
Summaries of chemical use in consumer products were developed
from information found in US EPA SRD (11), NLM HPD (12), and Scorecard (12). Major uses
were taken from IARC Monographs (9), NTP 11th ROC (4), NTP Study Reports (3), HSDB (10),
and PAN Pesticides Database (13). If a chemical could not be found in these sources, we
searched ToxNet (14), PubChem (15), and The Merck Index (16), and conducted searches by both
name and CAS No. using Google.
10 consumer products listed with EPA contain chemical. Some consumer uses include insecticides (sprays, household and commercial resin strips, and flea collars that are applied to animals (HSDB)), pet flea and tick products, agricultural chemicals (Scorecard.org); widely as an insecticide since 1961 to control internal and external parasites in livestock and domestic animals, to control insects in houses, and in crop protection (IARC 1991 vol.:53 p.267). Currently registered for use as a pesticide in the US (PAN Pesticides Database).
Occupational exposure to women
We extracted the total number of potentially exposed workers and the
number of potentially exposed female workers from the National Occupational Exposure
Survey (NOES) 1981-1983; we listed specific industry classifications if >5,000 women were
potentially exposed in that industry. Note: NOES does not include farm workers.
NOES 1981-1983-Total exposed: 24,205 Females exposed: 2,466 Occupational exposure will primarily be by inhalation and dermal contact in situations where the insecticide is used or stored (HSDB).
US EPA cancer classification
The US EPA Weight of Evidence Characterization of the
chemical’s carcinogenic potential is listed: Group A: Carcinogenic to humans; Group B:
Probably carcinogenic to humans. Group C: Possibly carcinogenic to humans. Group D: Not
classifiable as to human carcinogenicity. Group E: Evidence of non-carcinogenicity for
humans. NA: Not evaluated by US EPA (17).
B2: Probably Carcinogenic to Humans, inadequate evidence
US EPA Weight of Evidence narrative
US EPA narrative statement of overall weight of
evidence for carcinogenicity (animal, human, and other supportive data).
Significant increases in forestomach tumors in female and male B6C3F1 mice and leukemias and pancreatic acinar adenomas in Fischer 344 rats. Supporting evidence included observation of tumors at other sites in the rat and observation of mutagenicity for both dichlorvos and a major metabolite dichloroacetaldehyde. A structurally related material, dichloropropene, also induces forestomach tumors in rodents.
US EPA slope factor basis
Lists target organs used for estimating carcinogenic potency of the
chemical (17).
Oral: Forestomach tumors, pancreatic acinar adenoma, leukemia-mouse and rat
NIOSH Pocket Guide - potential carcinogen?
This field indicates whether NIOSH identifies the chemical as a potential
carcinogen for workers (yes/no) (24).
NA
OSHA-Is medical surveillance required?
This field indicates whether medical surveillance is
required for exposed workers and whether required surveillance includes breast exams or
mammography (25).
no
Risk assessments not reviewed for this chemical