Environment and Breast Cancer: Science Review
AboutCancer studies: Mammary gland tumors
Originating list
The list(s) or database(s) in which the chemical was identified as showing an
increase in mammary gland tumors. CPDB: Carcinogenic Potency Database, IARC:
International Agency for Research on Chemicals Monographs on the Evaluation of
Carcinogenic Risk of Chemicals to Man summaries, NTP TR: National Toxicology Program
(NTP) Technical Reports, NTP 11ROC: NTP 11th Report on Carcinogens, CCRIS: Chemical
Carcinogenesis Research Information Service.
Carcinogenicity Potency Database, IARC Monographs, Chemical Carcinogenesis Research Information System
Mammary gland tumor summary
A summary of findings related to mammary gland tumors, most
often excerpted from IARC Monographs or the NTP 11th ROC, and, in some cases,
supplemented by our evaluation of individual studies and reviews, is available for the priority
chemicals and 67 others.
Evidence of increased incidence and/or decreased latency of malignant and/or benign mammary tumors over a wide range of doses in female rats is sufficient to conclude that atrazine is a possible breast carcinogen.
Citations to review sources and individual studies reporting mammary gland tumors are listed below.
Citation
Source Type
Notes
International Agency for Research on Cancer, Monographs on the evaluation of carcinogenic risk of chemicals to man.VOL.: 73 (1999) (p. 59) Atrazine.
Review
Carcinogenic Potency Database 2005. Gold LS ST, Manley NB, Garfinkel GB, Ames BN. Summary Table by Chemical of Carcinogenicity Results in CPDB on 1485 Chemicals. 2005
Review
Pinter A, Torok G, Borzsonyi M, Surjan A, Csik M, Kelecsenyi Z, et al. Long-term carcinogenicity bioassay of the herbicide atrazine in F344 rats. Neoplasma 1990;37(5):533-44.
Innes JR, Ulland BM, Valerio MG, Petrucelli L, Fishbein L, Hart ER, et al. Bioassay of pesticides and industrial chemicals for tumorigenicity in mice: a preliminary note. J Natl Cancer Inst 1969;42(6):1101-14.
Primary Literature
Innes JRM, Bionetics Research Laboratories Inc. Evaluation of Carcinogenic, Teratogenic, and Mutagenic Activities of Selected Pesticides and Industrial Chemicals. Volume 1: Carcinogenic Study. In. Springfield, VA: National Technical Information Service; 1968
Primary Literature
Stevens JT, Breckenridge CB, Wetzel L. A risk characterization for atrazine: oncogenicity profile. J Toxicol Environ Health A 1999;56(2):69-109.
Primary Literature
Stevens JT, Breckenridge CB, Wetzel L. A risk characterization for atrazine: oncogenicity profile. J Toxicol Environ Health A 1999;56(2):69-109.
Primary Literature
Stevens JT, Breckenridge CB, Wetzel LT, Gillis JH, Luempert LG, 3rd, Eldridge JC. Hypothesis for mammary tumorigenesis in Sprague-Dawley rats exposed to certain triazine herbicides. J Toxicol Environ Health 1994;43(2):139-53.
Primary Literature
Thakur A, Wetzel L, Voelker R, Wakefield A. Results of a 2 year oncogenicity study in Fisher 344 rats with atrazine. In: Ballantine LG MJ, Hackett DS, editor. Triazine Herbicides: ACS Symposium Series 683. New York: American Chemical Society; 1998. p. 384-398.
Primary Literature
Wetzel LT, Luempert LG, 3rd, Breckenridge CB, Tisdel MO, Stevens JT, Thakur AK, et al. Chronic effects of atrazine on estrus and mammary tumor formation in female Sprague-Dawley and Fischer 344 rats. J Toxicol Environ Health 1994;43(2):169-82.
Primary Literature
National Toxicology Program 11th Report on Carcinogens, Table 1. Chemicals nominated to the National Toxicology Program for in-depth toxicological evaluation for carcinogenesis testing in fiscal years 1988-2003.
Review