Environment and Breast Cancer: Science Review
Cancer studies: Mammary gland tumors
The list(s) or database(s) in which the chemical was identified as showing an increase in mammary gland tumors. CPDB: Carcinogenic Potency Database, IARC: International Agency for Research on Chemicals Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man summaries, NTP TR: National Toxicology Program (NTP) Technical Reports, NTP 11ROC: NTP 11th Report on Carcinogens, CCRIS: Chemical Carcinogenesis Research Information Service.National Toxicology Program studies
Mammary gland tumor summary
A summary of findings related to mammary gland tumors, most often excerpted from IARC Monographs or the NTP 11th ROC, and, in some cases, supplemented by our evaluation of individual studies and reviews, is available for the priority chemicals and 67 others.NTP 11th ROC: When given to rats in their drinking water, the dihydrochloride salt of 3,3´-dimethylbenzidine increased the incidence of cancers of the mammary gland (adenocarcinomas) in females.
Citations to review sources and individual studies reporting mammary gland tumors are listed below.
International Agency for Research on Cancer, Monographs on the evaluation of carcinogenic risk of chemicals to man.VOL.: 1 (1972) (p. 87) 3,3'-dimethylbenzidine (o-Tolidine). Summary of Data Reported and Evaluation.
National Toxicology Program 11th Report on Carcinogens. 3,3'-dimethylbenzidine and dyes metabolized to 3,3'-dimethylbenzidine
Griswold DP, Jr., Casey AE, Weisburger EK, Weisburger JH. The carcinogenicity of multiple intragastric doses of aromatic and heterocyclic nitro or amino derivatives in young female sprague-dawley rats. Cancer Res. 1968 May;28(5):924-33.
National Toxicology Program Technical Report 390, 1991
National Toxicology Program 11th Report on Carcinogens, Table 1. Chemicals nominated to the National Toxicology Program for in-depth toxicological evaluation for carcinogenesis testing in fiscal years 1988-2003.