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3,3'-dimethylbenzidine
CAS RN 119-93-7



Cancer studies: Mammary gland tumors
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Originating list
The list(s) or database(s) in which the chemical was identified as showing an increase in mammary gland tumors. CPDB: Carcinogenic Potency Database, IARC: International Agency for Research on Chemicals Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man summaries, NTP TR: National Toxicology Program (NTP) Technical Reports, NTP 11ROC: NTP 11th Report on Carcinogens, CCRIS: Chemical Carcinogenesis Research Information Service.
National Toxicology Program studies
Mammary gland tumor summary
A summary of findings related to mammary gland tumors, most often excerpted from IARC Monographs or the NTP 11th ROC, and, in some cases, supplemented by our evaluation of individual studies and reviews, is available for the priority chemicals and 67 others.
NTP 11th ROC: When given to rats in their drinking water, the dihydrochloride salt of 3,3-dimethylbenzidine increased the incidence of cancers of the mammary gland (adenocarcinomas) in females.
Citations to review sources and individual studies reporting mammary gland tumors are listed below.
Citation
Source Type
Notes
International Agency for Research on Cancer, Monographs on the evaluation of carcinogenic risk of chemicals to man.VOL.: 1 (1972) (p. 87) 3,3'-dimethylbenzidine (o-Tolidine). Summary of Data Reported and Evaluation.
Review
Oral administration induced mammary tumors in female rats: Griswold 1968.
National Toxicology Program 11th Report on Carcinogens. 3,3'-dimethylbenzidine and dyes metabolized to 3,3'-dimethylbenzidine
Review
When given to rats in drinking water, increased the incidence of cancer of the mammary gland (adenocarcinomas) in females (IARC 1972, NTP 1991).
Griswold DP, Jr., Casey AE, Weisburger EK, Weisburger JH. The carcinogenicity of multiple intragastric doses of aromatic and heterocyclic nitro or amino derivatives in young female sprague-dawley rats. Cancer Res. 1968 May;28(5):924-33.
Primary Literature
From IARC
National Toxicology Program Technical Report 390, 1991
Primary Literature
National Toxicology Program 11th Report on Carcinogens, Table 1. Chemicals nominated to the National Toxicology Program for in-depth toxicological evaluation for carcinogenesis testing in fiscal years 1988-2003.
Review
Not nominated for NTP testing in 1998-2003.