Environment and Breast Cancer: Science Review
Cancer studies: Mammary gland tumors
The list(s) or database(s) in which the chemical was identified as showing an increase in mammary gland tumors. CPDB: Carcinogenic Potency Database, IARC: International Agency for Research on Chemicals Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man summaries, NTP TR: National Toxicology Program (NTP) Technical Reports, NTP 11ROC: NTP 11th Report on Carcinogens, CCRIS: Chemical Carcinogenesis Research Information Service.Carcinogenicity Potency Database, IARC Monographs, National Toxicology Program studies, Chemical Carcinogenesis Research Information System
Mammary gland tumor summary
A summary of findings related to mammary gland tumors, most often excerpted from IARC Monographs or the NTP 11th ROC, and, in some cases, supplemented by our evaluation of individual studies and reviews, is available for the priority chemicals and 67 others.NTP 11th ROC: When administered by gavage, 1,2-dichloroethane increased the incidence of mammary gland adenocarcinomas in female mice and female rats
Citations to review sources and individual studies reporting mammary gland tumors are listed below.
International Agency for Research on Cancer, Monographs on the evaluation of carcinogenic risk of chemicals to man.VOL.: 20 (1979 (p.429) 1,2-Dichloroethane. Summary of Data Reported and Evaluation.
International Agency for Research on Cancer, Monographs on the evaluation of carcinogenic risk of chemicals to man.VOL.: 71 (1999) (p. 501) 1,2-Dichloroethane.
Carcinogenic Potency Database 2005. Gold LS ST, Manley NB, Garfinkel GB, Ames BN. Summary Table by Chemical of Carcinogenicity Results in CPDB on 1485 Chemicals. 2005
National Toxicology Program 11th Report on Carcinogens. 1,2-Dichloroethane
Maltoni C, Valgimigli, L., and Scarnato, C. Long-term carcinogenic bioassays on ethylene dichloride administered by inhalation to rats and mice. In: B. Ames PI, R. Reitz, editor. Banbury Report 5 Ethylene Dichloride: A Potential Health Risk? Cold Spring Harbor, NY: Cold Spring Harbor Laboratory; 1980. p. 3-33.
Cheever KL, Cholakis JM, el-Hawari AM, Kovatch RM, Weisburger EK. Ethylene dichloride: the influence of disulfiram or ethanol on oncogenicity, metabolism, and DNA covalent binding in rats. Fundam Appl Toxicol 1990;14(2):243-61.
Nagano KN, T; Yamamoto, S; et al. Inhalation carcinogenesis studies of six halogenated hydrocarbons in rats and mice. In: Chiyotani KH, Y; Aizawa, Y, editor. Advances in the prevention of occupational respiratory diseases. Amsterdam: Elsevier Science; 1998.
National Toxicology Program Technical Report 55, 1978