Environment and Breast Cancer: Science Review

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Key References
Abbreviations
 

conjugated estrogens
CAS RN NA5

Chemical Summary
Exposure and Risk Assessment
Cancer Studies
 


Cancer studies: Mammary gland tumors
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Originating list
The list(s) or database(s) in which the chemical was identified as showing an increase in mammary gland tumors. CPDB: Carcinogenic Potency Database, IARC: International Agency for Research on Chemicals Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man summaries, NTP TR: National Toxicology Program (NTP) Technical Reports, NTP 11ROC: NTP 11th Report on Carcinogens, CCRIS: Chemical Carcinogenesis Research Information Service.
IARC Monographs
Mammary gland tumor summary
A summary of findings related to mammary gland tumors, most often excerpted from IARC Monographs or the NTP 11th ROC, and, in some cases, supplemented by our evaluation of individual studies and reviews, is available for the priority chemicals and 67 others.
Evidence of increased breast cancer in humans and increased mammary gland tumors in animals.
Citations to review sources and individual studies reporting mammary gland tumors are listed below.
Citation
Source Type
Notes
International Agency for Research on Cancer, Monographs on the evaluation of carcinogenic risk of chemicals to man.VOL.: 72 (1999) (p. 399) Post-menopausal oestrogen therapy (Group 1). Summary of Data Reported and Evaluation.
Review
"Information on the relationship between post-menopausal oestrogen therapy and risk for breast cancer is available from many epidemiological studies. A pooled analysis of the original data from 51 of those studies and a review of data from 15 cohort and 23 case control studies showed that in the majority of the studies there is a small increase in risk with longer duration of use (five years or more) in current and recent users. Although there is far less information about women who used post-menopausal oestrogen therapy and then ceased use, the increase in risk appears to cease several years after use has stopped. The increase in risk is predominantly for small localized carcinomas of the breast. There are insufficient data to determine whether the risk varies with type of compound or dose."
http://monographs.iarc.fr/ENG/Monographs/vol72/volume72.p...
International Agency for Research on Cancer, Monographs on the evaluation of carcinogenic risk of chemicals to man.VOL.: Supplement 7 (1987) (p. 280) Oestrogens, Steroidal. Summary of Data Reported and Evaluation.
Review
Does not mention mammary tumors.
http://monographs.iarc.fr/ENG/Monographs/suppl7/suppl7.pd...
National Toxicology Program 11th Report on Carcinogens. Estrogens, Steroidal
Review
Does not mention mammary tumors endpoint specifically in relation to conjugated oestrogens; however states estrogen compounds generally cause mammary tumors in rats (IARC 1999).
http://ntp.niehs.nih.gov/ntp/roc/eleventh/profiles/s084st...
National Toxicology Program 11th Report on Carcinogens, Table 1. Chemicals nominated to the National Toxicology Program for in-depth toxicological evaluation for carcinogenesis testing in fiscal years 1988-2003.
Review
Not nominated for NTP testing in 1998-2003.
http://ntp.niehs.nih.gov/ntp/roc/eleventh/tab1.pdf