Environment and Breast Cancer: Science Review
AboutCancer studies: Mammary gland tumors
Originating list
The list(s) or database(s) in which the chemical was identified as showing an
increase in mammary gland tumors. CPDB: Carcinogenic Potency Database, IARC:
International Agency for Research on Chemicals Monographs on the Evaluation of
Carcinogenic Risk of Chemicals to Man summaries, NTP TR: National Toxicology Program
(NTP) Technical Reports, NTP 11ROC: NTP 11th Report on Carcinogens, CCRIS: Chemical
Carcinogenesis Research Information Service.
IARC Monographs, Carcinogenicity Potency Database, Chemical Carcinogenesis Research Information System
Mammary gland tumor summary
A summary of findings related to mammary gland tumors, most
often excerpted from IARC Monographs or the NTP 11th ROC, and, in some cases,
supplemented by our evaluation of individual studies and reviews, is available for the priority
chemicals and 67 others.
Some chemicals (ptaquiloside, ecdysone) extracted from bracken fern have produced malignant mammary gland tumors in female rats and mice.
Citations to review sources and individual studies reporting mammary gland tumors are listed below.
Citation
Source Type
Notes
International Agency for Research on Cancer, Monographs on the evaluation of carcinogenic risk of chemicals to man.VOL.: 40 (1986) (p. 47) Bracken Fern. Summary of Data Reported and Evaluation.
Review
International Agency for Research on Cancer, Monographs on the evaluation of carcinogenic risk of chemicals to man.VOL.: Supplement 7 (1987) (p. 135) Bracken Fern. Summary of Data Reported and Evaluation.
Review
Carcinogenic Potency Database 2005. Gold LS ST, Manley NB, Garfinkel GB, Ames BN. Summary Table by Chemical of Carcinogenicity Results in CPDB on 1485 Chemicals. 2005
Review
National Library of Medicine. (CCRIS) Chemical Carcinogenesis Research Information System. [cited 2005 September 30]
Review
El-Mofty, M. M., Sakr, S. A., Rizk, A. M., and Moussa, E. A. Induction of breast and lung neoplastic lesions in mice by alpha ecdysone. Oncol. Rep. 1: 435-438(1994).
Primary literature
Hirono I, Aiso S, Hosaka S, Yamaji T, Haga M. Induction of mammary cancer in CD rats fed bracken diet. Carcinogenesis. 1983;4(7):885-7.
Primary Literature
Hirono I, Aiso S, Yamaji T, Mori H, Yamada K, Niwa H, et al. Carcinogenicity in rats of ptaquiloside isolated from bracken. Gann. 1984 Oct;75(10):833-6.
Primary Literature
National Toxicology Program 11th Report on Carcinogens, Table 1. Chemicals nominated to the National Toxicology Program for in-depth toxicological evaluation for carcinogenesis testing in fiscal years 1988-2003.
Review