Environment and Breast Cancer: Science Review


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wood dust methanol extract
CAS RN NA2



Cancer studies: Mammary gland tumors
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Originating list
The list(s) or database(s) in which the chemical was identified as showing an increase in mammary gland tumors. CPDB: Carcinogenic Potency Database, IARC: International Agency for Research on Chemicals Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man summaries, NTP TR: National Toxicology Program (NTP) Technical Reports, NTP 11ROC: NTP 11th Report on Carcinogens, CCRIS: Chemical Carcinogenesis Research Information Service.
IARC Monographs, National Toxicology Program 11th Report on Carcinogens
Mammary gland tumor summary
A summary of findings related to mammary gland tumors, most often excerpted from IARC Monographs or the NTP 11th ROC, and, in some cases, supplemented by our evaluation of individual studies and reviews, is available for the priority chemicals and 67 others.
NTP 11ROC: No tumors observed in several inhalation studies of wood dust. Dermal exposure to a methanol extract of beech wood dust resulted in a marginally significant dose-related increase in the incidence of mammary tumors (adenocarcinoma, adenoacanthoma, and mixed tumors) in female NMRI mice.
Only review sources are listed for this chemical because of lower likelihood of exposure.
Citation
Source Type
Notes
International Agency for Research on Cancer, Monographs on the evaluation of carcinogenic risk of chemicals to man.VOL.: 62 (1995) (p. 35) Wood Dust. Summary of Data Reported and Evaluation.
Review
The mutagenic fraction of a methanol extract of beech wood dust was tested for carcinogenicity by skin application in one study in mice. Although a marginally significant, dose-dependent increase in the incidence of mammary tumours was observed, these results cannot be used in an evaluation of the carcinogenicity of wood dust per se.
National Toxicology Program 11th Report on Carcinogens. Wood dust
Review
Dermal exposure to a methanol extract of beech wood dust resulted in a significant dose-related increase in the incidence of mammary tumors (adenocarcinoma, adenocanthoma, and mixed tumors) in female NMRI mice (IARC 1995).
National Toxicology Program 11th Report on Carcinogens, Table 1. Chemicals nominated to the National Toxicology Program for in-depth toxicological evaluation for carcinogenesis testing in fiscal years 1988-2003.
Review
Chemical name: organic particulate; Nominated by UAW in 1994, 2000. Rationale: Concern about health effects of chemicals and combinations of chemicals (including particulates) found in the industrial environment in substantial levels. Current NTP Status: Nominated for toxicity testing; under review; Wood dust, flour dust.