Environment and Breast Cancer: Science Review

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CAS RN 99-59-2

Cancer studies: Mammary gland tumors
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Originating list
The list(s) or database(s) in which the chemical was identified as showing an increase in mammary gland tumors. CPDB: Carcinogenic Potency Database, IARC: International Agency for Research on Chemicals Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man summaries, NTP TR: National Toxicology Program (NTP) Technical Reports, NTP 11ROC: NTP 11th Report on Carcinogens, CCRIS: Chemical Carcinogenesis Research Information Service.
IARC Monographs
Mammary gland tumor summary
A summary of findings related to mammary gland tumors, most often excerpted from IARC Monographs or the NTP 11th ROC, and, in some cases, supplemented by our evaluation of individual studies and reviews, is available for the priority chemicals and 67 others.
A 1978 study by NTP showed some evidence of mammary gland tumors, but weaknesses in the study limit interpretability. An NTP study of 5-nitro-ortho-anisidine did not find mammary gland tumors.
Citations to review sources and individual studies reporting mammary gland tumors are listed below.
Source Type
International Agency for Research on Cancer, Monographs on the evaluation of carcinogenic risk of chemicals to man.VOL.: 27 (1982) (p. 133) 5-Nitro-ortho-anisidine. Summary of Data Reported and Evaluation.
Administration in diet induced mammary adenocarcinomas in female rats: National Cancer Institute 1978. [The Working Group noted that control and treated rats were received in separate shipments and that low-dose rats were obtained from a different commercial source than their controls.]
Carcinogenic Potency Database 2005. Gold LS ST, Manley NB, Garfinkel GB, Ames BN. Summary Table by Chemical of Carcinogenicity Results in CPDB on 1485 Chemicals. 2005
One of one study reports mammary tumors: NTP TR127.
National Toxicology Program Technical Report 127, 1978
Primary Literature
Mammary gland adenocarcinomas were increased in low dose animals and slightly increased in high dose animals. Weaknesses of study include lack of appropriate controls and high mortality.
National Toxicology Program 11th Report on Carcinogens, Table 1. Chemicals nominated to the National Toxicology Program for in-depth toxicological evaluation for carcinogenesis testing in fiscal years 1988-2003.
Not nominated for NTP testing in 1998-2003.