Environment and Breast Cancer: Science Review

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Key References
Abbreviations
 

nitrobenzene
CAS RN 98-95-3

Chemical Summary
Exposure and Risk Assessment
Cancer Studies
 


Cancer studies: Mammary gland tumors
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Originating list
The list(s) or database(s) in which the chemical was identified as showing an increase in mammary gland tumors. CPDB: Carcinogenic Potency Database, IARC: International Agency for Research on Chemicals Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man summaries, NTP TR: National Toxicology Program (NTP) Technical Reports, NTP 11ROC: NTP 11th Report on Carcinogens, CCRIS: Chemical Carcinogenesis Research Information Service.
Carcinogenicity Potency Database, National Toxicology Program 11th Report on Carcinogens, Chemical Carcinogenesis Research Information System
Mammary gland tumor summary
A summary of findings related to mammary gland tumors, most often excerpted from IARC Monographs or the NTP 11th ROC, and, in some cases, supplemented by our evaluation of individual studies and reviews, is available for the priority chemicals and 67 others.
NTP 11th ROC: Exposure to nitrobenzene caused mammary gland tumors in female B6C3F1 mice.
Citations to review sources and individual studies reporting mammary gland tumors are listed below.
Citation
Source Type
Notes
International Agency for Research on Cancer, Monographs on the evaluation of carcinogenic risk of chemicals to man.VOL.: 65 (1996) (p. 381) Nitrobenzene. Summary of Data Reported and Evaluation.
Review
Inhalation exposure induced mammary tumors in female mice: Cattley 1994.
http://monographs.iarc.fr/ENG/Monographs/vol65/volume65.p...
Carcinogenic Potency Database 2005. Gold LS ST, Manley NB, Garfinkel GB, Ames BN. Summary Table by Chemical of Carcinogenicity Results in CPDB on 1485 Chemicals. 2005
Review
One of one study reports mammary tumors: Cattley 1994.
http://potency.berkeley.edu/pdfs/ChemicalTable.pdf
National Toxicology Program 11th Report on Carcinogens. Nitrobenzene.
Review
Caused mammary gland tumors in female B6C3F1 mice (Cattley et al. 1994). -Cattley, R. C., J. I. Everitt, E. A. Gross, O. R. Moss, T. E. Hamm, Jr. and J. A. Popp. 1994. Carcinogenicity and toxicity of inhaled nitrobenzene in B6C3F1 mice and F344 and CD rats [published erratum appears in Fundam Appl Toxicol 1995 Apr;25(1):159]. Fundam Appl Toxicol 22(3): 328-40.
http://ntp.niehs.nih.gov/ntp/roc/eleventh/profiles/s121zn...
Cattley RC, Everitt JI, Gross EA, Moss OR, Hamm TE, Jr., Popp JA. Carcinogenicity and toxicity of inhaled nitrobenzene in B6C3F1 mice and F344 and CD rats. Fundam Appl Toxicol 1994;22(3):328-40.
Primary Literature
National Toxicology Program 11th Report on Carcinogens, Table 1. Chemicals nominated to the National Toxicology Program for in-depth toxicological evaluation for carcinogenesis testing in fiscal years 1988-2003.
Review
Not nominated for NTP testing in 1998-2003.
http://ntp.niehs.nih.gov/ntp/roc/eleventh/tab1.pdf