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Key References
Abbreviations
 

ortho-aminoazotoluene
CAS RN 97-56-3

Chemical Summary
Exposure and Risk Assessment
Cancer Studies
 


Cancer studies: Mammary gland tumors
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Originating list
The list(s) or database(s) in which the chemical was identified as showing an increase in mammary gland tumors. CPDB: Carcinogenic Potency Database, IARC: International Agency for Research on Chemicals Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man summaries, NTP TR: National Toxicology Program (NTP) Technical Reports, NTP 11ROC: NTP 11th Report on Carcinogens, CCRIS: Chemical Carcinogenesis Research Information Service.
National Toxicology Program 11th Report on Carcinogens
Mammary gland tumor summary
A summary of findings related to mammary gland tumors, most often excerpted from IARC Monographs or the NTP 11th ROC, and, in some cases, supplemented by our evaluation of individual studies and reviews, is available for the priority chemicals and 67 others.
NTP 11ROC: Three female hamsters had mammary adenocarcinomas believed to be related to the treatment.
Only review sources are listed for this chemical because of lower likelihood of exposure.
Citation
Source Type
Notes
International Agency for Research on Cancer, Monographs on the evaluation of carcinogenic risk of chemicals to man.VOL.: 8 (1975) (p. 61)
Review
In a study of 25 male Hamsters and 15 female hamsters:"3 females had mammary adenocarcinomas believed to be related to the treatment": Tomatis et.al. (1961)
http://monographs.iarc.fr/ENG/Monographs/vol8/volume8.pdf...
Carcinogenic Potency Database 2005. Gold LS ST, Manley NB, Garfinkel GB, Ames BN. Summary Table by Chemical of Carcinogenicity Results in CPDB on 1485 Chemicals. 2005
Review
Both studies listed do not report mammary tumors: Walker 1973 and Waters 1937.
http://potency.berkeley.edu/pdfs/ChemicalTable.pdfpotency...
National Toxicology Program 11th Report on Carcinogens
Review
When administered in diet, mammary tumors developed in female hamsters. References 1975 IARC.
http://ntp.niehs.nih.gov/ntp/roc/eleventh/profiles/s009am...
Walker AI, Thorpe E, Stevenson DE. The toxicology of dieldrin (HEOD). I. Long-term oral toxicity studies in mice. Food Cosmet Toxicol 1973;11(3):415-32.
Primary Literature
A study listed by CPDB 2005 that did not report mammary tumors. All female rats had died before week 44 (note that NTP control rats develop mammary tumors at about 109 wks). Mammary glands were not examined histologically, but every animal received a gross dissection.
Waters L. o-Aminoazotoluene as a carcinogenic agent. Yale J. Biol. Med. 1937;10:179-184.
Primary Literature
A study listed by CPDB 2005 that did not report mammary tumors. Mammary glands were not examined and most female albino rats (11/18) died of an infection or were killed before 46 wks of exposure (note that NTP control rats develop mammary tumors at about 109 wks). Focus was on liver tumors.
Tomatis L, Della Porta G, Shubik P. Urinary bladder and liver cell tumors induced in hamsters with o-aminoazotoluene. Cancer Res 1961;21:1513-7.
Primary Literature
From IARC, review postponed.
National Toxicology Program 11th Report on Carcinogens, Table 1. Chemicals nominated to the National Toxicology Program for in-depth toxicological evaluation for carcinogenesis testing in fiscal years 1988-2003.
Review
Not nominated for NTP testing in 1998-2003.
http://ntp.niehs.nih.gov/ntp/roc/eleventh/tab1.pdf