Environment and Breast Cancer: Science Review

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Key References
Abbreviations
 

1,2,3-trichloropropane
CAS RN 96-18-4

Chemical Summary
Exposure and Risk Assessment
Cancer Studies
 


Cancer studies: Mammary gland tumors
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Originating list
The list(s) or database(s) in which the chemical was identified as showing an increase in mammary gland tumors. CPDB: Carcinogenic Potency Database, IARC: International Agency for Research on Chemicals Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man summaries, NTP TR: National Toxicology Program (NTP) Technical Reports, NTP 11ROC: NTP 11th Report on Carcinogens, CCRIS: Chemical Carcinogenesis Research Information Service.
Carcinogenicity Potency Database, National Toxicology Program studies, National Toxicology Program 11th Report on Carcinogens, IARC Monographs, Chemical Carcinogenesis Research Information System
Mammary gland tumor summary
A summary of findings related to mammary gland tumors, most often excerpted from IARC Monographs or the NTP 11th ROC, and, in some cases, supplemented by our evaluation of individual studies and reviews, is available for the priority chemicals and 67 others.
NTP 11th ROC: Female rats had increased incidence of tumors in the mammary gland.
Citations to review sources and individual studies reporting mammary gland tumors are listed below.
Citation
Source Type
Notes
International Agency for Research on Cancer, Monographs on the evaluation of carcinogenic risk of chemicals to man.VOL.: 63 (1995) (p. 223) 1,2,3-Trichloropropane.
Review
When administered orally, increased incidences of mammary gland tumors in female rats: NTP TR384
http://monographs.iarc.fr/ENG/Monographs/vol63/volume63.p...
Carcinogenic Potency Database 2005. Gold LS ST, Manley NB, Garfinkel GB, Ames BN. Summary Table by Chemical of Carcinogenicity Results in CPDB on 1485 Chemicals. 2005
Review
One of one study reports mammary tumors: NTP TR384.
http://potency.berkeley.edu/pdfs/ChemicalTable.pdfpotency...
National Toxicology Program 11th Report on Carcinogens. 1,2,3-Trichloropropane
Review
When administered by gavage for 2 years, increased incidences of mammary gland tumors in female rats (NTP 1993, Irwin et al. 1995, IARC 1995). -Irwin, R. D., J. K. Haseman and S. L. Eustis. 1995. 1,2,3-Trichloropropane: a multisite carcinogen in rats and mice. Fundam Appl Toxicol 25(2): 241-52. (mentions mammary tumors in abstract)
http://ntp.niehs.nih.gov/ntp/roc/eleventh/profiles/s182tc...
National Toxicology Program Technical Report 384, 1993
Primary Literature
http://ntp.niehs.nih.gov/ntp/htdocs/LT_rpts/tr384.pdf