Environment and Breast Cancer: Science Review
Cancer studies: Mammary gland tumors
The list(s) or database(s) in which the chemical was identified as showing an increase in mammary gland tumors. CPDB: Carcinogenic Potency Database, IARC: International Agency for Research on Chemicals Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man summaries, NTP TR: National Toxicology Program (NTP) Technical Reports, NTP 11ROC: NTP 11th Report on Carcinogens, CCRIS: Chemical Carcinogenesis Research Information Service.IARC Monographs, National Toxicology Program studies, Chemical Carcinogenesis Research Information System
Mammary gland tumor summary
A summary of findings related to mammary gland tumors, most often excerpted from IARC Monographs or the NTP 11th ROC, and, in some cases, supplemented by our evaluation of individual studies and reviews, is available for the priority chemicals and 67 others.There is only one study, an NTP study, of this chemical and it used a dermal exposure. DBP caused increased tumors at multiple sites, including the mammary gland (female rats). Tumors (not necessarily mammary) were observed in all animals, even at the lowest doses.
Citations to review sources and individual studies reporting mammary gland tumors are listed below.
International Agency for Research on Cancer, Monographs on the evaluation of carcinogenic risk of chemicals to man.VOL.: 77 (2000) (p. 439)
Carcinogenic Potency Database 2005. Gold LS ST, Manley NB, Garfinkel GB, Ames BN. Summary Table by Chemical of Carcinogenicity Results in CPDB on 1485 Chemicals. 2005
National Toxicology Program 11th Report on Carcinogens. 2,3-Dibromo-1-Propanol.
National Toxicology Program Technical Report 400, 1993
Eustis SL, Haseman JK, Mackenzie WF, Abdo KM. Toxicity and carcinogenicity of 2,3-dibromo-1-propanol in F344/N rats and B6C3F1 mice. Fundam Appl Toxicol 1995;26(1):41-50.