Environment and Breast Cancer: Science Review

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CAS RN 96-13-9

Cancer studies: Mammary gland tumors
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Originating list
The list(s) or database(s) in which the chemical was identified as showing an increase in mammary gland tumors. CPDB: Carcinogenic Potency Database, IARC: International Agency for Research on Chemicals Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man summaries, NTP TR: National Toxicology Program (NTP) Technical Reports, NTP 11ROC: NTP 11th Report on Carcinogens, CCRIS: Chemical Carcinogenesis Research Information Service.
IARC Monographs, National Toxicology Program studies, Chemical Carcinogenesis Research Information System
Mammary gland tumor summary
A summary of findings related to mammary gland tumors, most often excerpted from IARC Monographs or the NTP 11th ROC, and, in some cases, supplemented by our evaluation of individual studies and reviews, is available for the priority chemicals and 67 others.
There is only one study, an NTP study, of this chemical and it used a dermal exposure. DBP caused increased tumors at multiple sites, including the mammary gland (female rats). Tumors (not necessarily mammary) were observed in all animals, even at the lowest doses.
Citations to review sources and individual studies reporting mammary gland tumors are listed below.
Source Type
International Agency for Research on Cancer, Monographs on the evaluation of carcinogenic risk of chemicals to man.VOL.: 77 (2000) (p. 439)
Skin application studies (which CPDB doesn't cover): NTP TR400 and Eustis et al., 1995
Carcinogenic Potency Database 2005. Gold LS ST, Manley NB, Garfinkel GB, Ames BN. Summary Table by Chemical of Carcinogenicity Results in CPDB on 1485 Chemicals. 2005
Not listed.
National Toxicology Program 11th Report on Carcinogens. 2,3-Dibromo-1-Propanol.
Refers to the NTP 1993 study but does not list mammary tumors as one of the endpoints. Does not list any reference to mammary tumors. Does say "there is an increased incidence of malignant and/or a combination of malignant and benign tumors at multiple tissue sites in multiple species of experimental animals". Reference is the NTP 1993 report.
National Toxicology Program Technical Report 400, 1993
Primary Literature

experimental details
Increase of mammary tumors in female rats. Rats: 0,188,375 mg/kg; Female rats: 0/50, 0/50, 5/50 adenocarcinoma. Clear evidence of carcinogenic activity in both sexes of both species (total organs). Mammary tumors listed as cancer type contributing to the determination for female rats. Study ended before 1 yr because of viral infection dangerous to humans.
Eustis SL, Haseman JK, Mackenzie WF, Abdo KM. Toxicity and carcinogenicity of 2,3-dibromo-1-propanol in F344/N rats and B6C3F1 mice. Fundam Appl Toxicol 1995;26(1):41-50.
Primary Literature
From IARC, review postponed.