Environment and Breast Cancer: Science Review

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Key References
Abbreviations
 

2,4-diaminotoluene
CAS RN 95-80-7

Chemical Summary
Exposure and Risk Assessment
Cancer Studies
 


Cancer studies: Mammary gland tumors
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Originating list
The list(s) or database(s) in which the chemical was identified as showing an increase in mammary gland tumors. CPDB: Carcinogenic Potency Database, IARC: International Agency for Research on Chemicals Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man summaries, NTP TR: National Toxicology Program (NTP) Technical Reports, NTP 11ROC: NTP 11th Report on Carcinogens, CCRIS: Chemical Carcinogenesis Research Information Service.
Carcinogenicity Potency Database, National Toxicology Program studies, Chemical Carcinogenesis Research Information System
Mammary gland tumor summary
A summary of findings related to mammary gland tumors, most often excerpted from IARC Monographs or the NTP 11th ROC, and, in some cases, supplemented by our evaluation of individual studies and reviews, is available for the priority chemicals and 67 others.
NTP 11th ROC: When administered in the diet, 2,4-diaminotoluene increased the incidence of carcinomas or adenomas of the mammary gland in female rats.
Citations to review sources and individual studies reporting mammary gland tumors are listed below.
Citation
Source Type
Notes
International Agency for Research on Cancer, Monographs on the evaluation of carcinogenic risk of chemicals to man.VOL.: 16 (1978) (p. 83). 2,4-Diaminotoluene. Summary of Data Reported and Evaluation
Review
No summaries of the studies indicated increased mammary tumors due to treatment.
http://monographs.iarc.fr/ENG/Monographs/vol16/volume16.p...
Carcinogenic Potency Database 2005. Gold LS ST, Manley NB, Garfinkel GB, Ames BN. Summary Table by Chemical of Carcinogenicity Results in CPDB on 1485 Chemicals. 2005
Review
One of one study notes mammary tumors: NTP TR162.
http://potency.berkeley.edu/pdfs/ChemicalTable.pdfpotency...
National Toxicology Program 11th Report on Carcinogens. 2,4-diaminotoluene.
Review
When adminisitered in diet, female rats had an increase in mammary tumors. Refers to IARC 1978, 1986 and NCI (NTP) TR162.
http://ntp.niehs.nih.gov/ntp/roc/eleventh/profiles/s057di...
National Toxicology Program Technical Report 162, 1979
Primary Literature

experimental details
Increases in malignant mammary tumors in female rats and benign tumors in female rats. Time weighted average dose was 79 ppm (low-dose males and females) for 103 wks, 176 ppm (high dose males) for 79 wks, 171 ppm (high dose females) for 84 wks. Female rats: 0/20, 9/50, 8/50 carcinoma Female rats: 0/20, 1/50, 1/50 other malignant tumors Authors acknowledge poor survival rates in rats may have resulted in fewer metastases of mammary tumors.
http://ntp.niehs.nih.gov/ntp/htdocs/LT_rpts/tr162.pdf