Environment and Breast Cancer: Science Review

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CAS RN 79-06-1

Cancer studies: Mammary gland tumors
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Originating list
The list(s) or database(s) in which the chemical was identified as showing an increase in mammary gland tumors. CPDB: Carcinogenic Potency Database, IARC: International Agency for Research on Chemicals Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man summaries, NTP TR: National Toxicology Program (NTP) Technical Reports, NTP 11ROC: NTP 11th Report on Carcinogens, CCRIS: Chemical Carcinogenesis Research Information Service.
Carcinogenicity Potency Database, IARC Monographs, National Toxicology Program 11th Report on Carcinogens, Chemical Carcinogenesis Research Information System
Mammary gland tumor summary
A summary of findings related to mammary gland tumors, most often excerpted from IARC Monographs or the NTP 11th ROC, and, in some cases, supplemented by our evaluation of individual studies and reviews, is available for the priority chemicals and 67 others.
NTP 11th ROC: When administered in the drinking water, acrylamide increased the incidence of mammary adenomas and adenocarcinomas in female rats.
Citations to review sources and individual studies reporting mammary gland tumors are listed below.
Source Type
International Agency for Research on Cancer, Monographs on the evaluation of carcinogenic risk of chemicals to man.VOL.: 60 (1994) (p. 389) Acrylamide.
One experiment in rats exposed by oral administration increased incidences of mammary tumors in female rats: Johnson 1986.
Carcinogenic Potency Database 2005. Gold LS ST, Manley NB, Garfinkel GB, Ames BN. Summary Table by Chemical of Carcinogenicity Results in CPDB on 1485 Chemicals. 2005
Two of two studies indicated mammary tumors: Johnson 1988 and Friedman 1995.
National Toxicology Program 11th Report on Carcinogens.
When administered in drinking water, increased the incidences of mammary adenomas and adenocarcinomas in female rats (IARC 1986, 1987, 1994).
Friedman MA, Dulak LH, Stedham MA. A lifetime oncogenicity study in rats with acrylamide. Fundam Appl Toxicol 1995;27(1):95-105.
Primary Literature
Johnson KA, Gorzinski SJ, Bodner KM, Campbell RA, Wolf CH, Friedman MA, et al. Chronic toxicity and oncogenicity study on acrylamide incorporated in the drinking water of Fischer 344 rats. Toxicol Appl Pharmacol 1986;85(2):154-68.
Primary Literature
National Toxicology Program 11th Report on Carcinogens, Table 1. Chemicals nominated to the National Toxicology Program for in-depth toxicological evaluation for carcinogenesis testing in fiscal years 1988-2003.
Nominated by FDA 2003. Current NTP Status: Selected for toxicity and carcinogenicity testing. Rationale: nomination: - Inadequate information to assess human health risks - Widespread exposure in food - Acrylamide metabolized to glycidamide which forms DNA adducts