Environment and Breast Cancer: Science Review


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2-methylaziridine
CAS RN 75-55-8



Cancer studies: Mammary gland tumors
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Originating list
The list(s) or database(s) in which the chemical was identified as showing an increase in mammary gland tumors. CPDB: Carcinogenic Potency Database, IARC: International Agency for Research on Chemicals Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man summaries, NTP TR: National Toxicology Program (NTP) Technical Reports, NTP 11ROC: NTP 11th Report on Carcinogens, CCRIS: Chemical Carcinogenesis Research Information Service.
National Toxicology Program 11th Report on Carcinogens, Chemical Carcinogenesis Research Information System
Mammary gland tumor summary
A summary of findings related to mammary gland tumors, most often excerpted from IARC Monographs or the NTP 11th ROC, and, in some cases, supplemented by our evaluation of individual studies and reviews, is available for the priority chemicals and 67 others.
NTP 11ROC: When administered by oral gavage or in the diet, 2-methylaziridine induced mammary adenocarcinomas in female rats.
Citations to review sources and individual studies reporting mammary gland tumors are listed below.
Citation
Source Type
Notes
International Agency for Research on Cancer, Monographs on the evaluation of carcinogenic risk of chemicals to man.VOL.: 71 (1999) (p.1497) 2-Mehtylaziridine. Summary of Data Reported and Evaluation.
Review
Does not mention mammary tumors.
National Toxicology Program 11th Report on Carcinogens. 2-Methylaziridine (Propylenimine)
Review
When administered by oral gavage or in the diet, induced mammary adenocarcinomas in female rats (IARC 1975, Weisburger et al. 1981). -Weisburger, E. K., B. M. Ulland, J. Nam, J. J. Gart and J. H. Weisburger. 1981. Carcinogenicity tests of certain environmental and industrial chemicals. J Natl Cancer Inst 67(1): 75-88.
National Toxicology Program 11th Report on Carcinogens, Table 1. Chemicals nominated to the National Toxicology Program for in-depth toxicological evaluation for carcinogenesis testing in fiscal years 1988-2003.
Review
Not nominated for NTP testing in 1998-2003.