Environment and Breast Cancer: Science Review
Cancer studies: Mammary gland tumors
The list(s) or database(s) in which the chemical was identified as showing an increase in mammary gland tumors. CPDB: Carcinogenic Potency Database, IARC: International Agency for Research on Chemicals Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man summaries, NTP TR: National Toxicology Program (NTP) Technical Reports, NTP 11ROC: NTP 11th Report on Carcinogens, CCRIS: Chemical Carcinogenesis Research Information Service.Carcinogenicity Potency Database, National Toxicology Program studies, IARC Monographs, Chemical Carcinogenesis Research Information System
Mammary gland tumor summary
A summary of findings related to mammary gland tumors, most often excerpted from IARC Monographs or the NTP 11th ROC, and, in some cases, supplemented by our evaluation of individual studies and reviews, is available for the priority chemicals and 67 others.High levels of methylene chloride were associated with benign mammary tumors in rats as well as an increase in the number of mammary tumors per animal. Four studies reported mammary turmors. NTP 11th ROC: Methylene chloride inhalation increased the incidence of fibroadenoma of the mammary gland in female rats. There is some evidence of the carcinogenicity of methylene chloride in male rats, as shown by an increased incidence of fibroadenomas of the mammary gland.
Citations to review sources and individual studies reporting mammary gland tumors are listed below.
International Agency for Research on Cancer, Monographs on the evaluation of carcinogenic risk of chemicals to man.VOL.: 71 (1999) (p. 251). Dichloromethane.
Carcinogenic Potency Database 2005. Gold LS ST, Manley NB, Garfinkel GB, Ames BN. Summary Table by Chemical of Carcinogenicity Results in CPDB on 1485 Chemicals. 2005
National Toxicology Program 11th Report on Carcinogens.
Burek JD, Nitschke KD, Bell TJ, Wackerle DL, Childs RC, Beyer JE, et al. Methylene chloride: a two-year inhalation toxicity and oncogenicity study in rats and hamsters. Fundam Appl Toxicol 1984;4(1):30-47.
Maltoni C, Cotti G, Perino G. Long-term carcinogenicity bioassays on methylene chloride administered by ingestion to Sprague-Dawley rats and Swiss mice and by inhalation to Sprague-Dawley rats. Ann N Y Acad Sci 1988;534:352-66.
National Toxicology Program Technical Report 306, 1986
Nitschke KD, Burek JD, Bell TJ, Kociba RJ, Rampy LW, McKenna MJ. Methylene chloride: a 2-year inhalation toxicity and oncogenicity study in rats. Fundam Appl Toxicol 1988;11(1):48-59.
Kari FW, Foley JF, Seilkop SK, Maronpot RR, Anderson MW. Effect of varying exposure regimens on methylene chloride-induced lung and liver tumors in female B6C3F1 mice. Carcinogenesis 1993;14(5):819-26.
Serota DG, Thakur AK, Ulland BM, Kirschman JC, Brown NM, Coots RH, et al. A two-year drinking-water study of dichloromethane in rodents. I. Rats. Food Chem Toxicol 1986;24(9):951-8.
Serota DG, Thakur AK, Ulland BM, Kirschman JC, Brown NM, Coots RH, et al. A two-year drinking-water study of dichloromethane in rodents. II. Mice. Food Chem Toxicol 1986;24(9):959-63.
US EPA. Health Assessment Document for Dichloromethane (Methylene Chloride). Final Report (EPA/600/8-82/004F). In: Office of Health and Environmental Assessment; 1985.