Environment and Breast Cancer: Science Review

Search the Mammary Carcinogens Reviews Database

Trp-P-2 acetate
CAS RN 72254-58-1

Cancer studies: Mammary gland tumors
Print this page
Originating list
The list(s) or database(s) in which the chemical was identified as showing an increase in mammary gland tumors. CPDB: Carcinogenic Potency Database, IARC: International Agency for Research on Chemicals Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man summaries, NTP TR: National Toxicology Program (NTP) Technical Reports, NTP 11ROC: NTP 11th Report on Carcinogens, CCRIS: Chemical Carcinogenesis Research Information Service.
Carcinogenicity Potency Database
Mammary gland tumor summary
A summary of findings related to mammary gland tumors, most often excerpted from IARC Monographs or the NTP 11th ROC, and, in some cases, supplemented by our evaluation of individual studies and reviews, is available for the priority chemicals and 67 others.
Coming soon
Citations to review sources and individual studies reporting mammary gland tumors are listed below.
Source Type
International Agency for Research on Cancer, Monographs on the evaluation of carcinogenic risk of chemicals to man.VOL.: 31 (1983) (p. 255) TRP-P-2 and its acetate. Summary of Data Reported and Evaluation.
Does not mention mammary tumors.
Carcinogenic Potency Database 2005. Gold LS ST, Manley NB, Garfinkel GB, Ames BN. Summary Table by Chemical of Carcinogenicity Results in CPDB on 1485 Chemicals. 2005
One of three studies reports mammary tumors: Takahashi 1993. Two studies did not report mammary tumors: Matsukura 1981 and Hosaka 1991.
Takahashi M, Toyoda K, Aze Y, Furuta K, Mitsumori K, Hayashi Y. The rat urinary bladder as a new target of heterocyclic amine carcinogenicity: tumor induction by 3-amino-1-methyl-5H-pyrido[4,3-b]indole acetate. Jpn J Cancer Res 1993;84(8):852-8.
Primary Literature
Hosaka S, Matsushima T, Hirono I, Sugimura T. Carcinogenic activity of 3-amino-1-methyl-5H-pyrido [4,3-b]indole (Trp-P-2), a pyrolysis product of tryptophan. Cancer Lett 1981;13(1):23-8.
Primary Literature
A study listed by CPDB 2005 that did not report mammary tumors.
Matsukura N, Kawachi T, Morino K, Ohgaki H, Sugimura T, Takayama S. Carcinogenicity in mice of mutagenic compounds from a tryptophan pyrolyzate. Science 1981;213(4505):346-7.
Primary Literature
A study listed by CPDB 2005 that did not report mammary tumors.
National Toxicology Program 11th Report on Carcinogens, Table 1. Chemicals nominated to the National Toxicology Program for in-depth toxicological evaluation for carcinogenesis testing in fiscal years 1988-2003.
Not nominated for NTP testing in 1998-2003.