Environment and Breast Cancer: Science Review

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Key References
Abbreviations
 

ortho-toluidine hydrochloride
CAS RN 636-21-5

Chemical Summary
Exposure and Risk Assessment
Cancer Studies
 


Cancer studies: Mammary gland tumors
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Originating list
The list(s) or database(s) in which the chemical was identified as showing an increase in mammary gland tumors. CPDB: Carcinogenic Potency Database, IARC: International Agency for Research on Chemicals Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man summaries, NTP TR: National Toxicology Program (NTP) Technical Reports, NTP 11ROC: NTP 11th Report on Carcinogens, CCRIS: Chemical Carcinogenesis Research Information Service.
Carcinogenicity Potency Database, National Toxicology Program studies, National Toxicology Program 11th Report on Carcinogens, IARC Monographs
Mammary gland tumor summary
A summary of findings related to mammary gland tumors, most often excerpted from IARC Monographs or the NTP 11th ROC, and, in some cases, supplemented by our evaluation of individual studies and reviews, is available for the priority chemicals and 67 others.
NTP 11th ROC: When administered in the diet, o-toluidine hydrochloride increased the incidence of mammary gland fibroadenomas and adenomas in female rats.
Citations to review sources and individual studies reporting mammary gland tumors are listed below.
Citation
Source Type
Notes
National Toxicology Program Technical Report 153, 1979.
Primary Literature
http://ntp.niehs.nih.gov/ntp/htdocs/LT_rpts/tr153.pdf
International Agency for Research on Cancer, Monographs on the evaluation of carcinogenic risk of chemicals to man.VOL.: 77 (2000) (p. 267) ortho-Toluidine. Summary of Data Reported and Evaluation.
Review
Administration by diet induced mammary tumors in male rats: Hecht 1982. Administration by diet induced mammary tumors in female rats: National Cancer Institute 1979.
http://monographs.iarc.fr/ENG/Monographs/vol77/volume77.p...
Carcinogenic Potency Database 2005. Gold LS ST, Manley NB, Garfinkel GB, Ames BN. Summary Table by Chemical of Carcinogenicity Results in CPDB on 1485 Chemicals. 2005
Review
Two of three studies report mammary tumors: NTP TR153 and Hecht 1982. One study did not report mammary tumors: Weisburger 1978.
http://potency.berkeley.edu/pdfs/ChemicalTable.pdfpotency...
National Toxicology Program 11th Report on Carcinogens. o-Toluidine and o-Toluidine Hydrochloride
Review
Does not mention mammary tumors specificially in relation to o-Toluidine. Does mention mammary tumors in relation to o-toluidine hydrochloride (IARC 1978, 1982, 1987, 2000).
http://ntp.niehs.nih.gov/ntp/roc/eleventh/profiles/s178ot...
Hecht SS, El-Bayoumy K, Rivenson A, Fiala E. Comparative carcinogenicity of o-toluidine hydrochloride and o-nitrosotoluene in F-344 rats. Cancer Lett. 1982 May-Jun;16(1):103-8.
Primary Literature
Weisburger EK, Russfield AB, Homburger F, Weisburger JH, Boger E, Van Dongen CG, et al. Testing of twenty-one environmental aromatic amines or derivatives for long-term toxicity or carcinogenicity. J Environ Pathol Toxicol. 1978 Nov-Dec;2(2):325-56.
Primary Literature
A study listed by CPDB 2005 that did not report mammary tumors.
National Toxicology Program 11th Report on Carcinogens, Table 1. Chemicals nominated to the National Toxicology Program for in-depth toxicological evaluation for carcinogenesis testing in fiscal years 1988-2003.
Review
Not nominated for NTP testing in 1998-2003.
http://ntp.niehs.nih.gov/ntp/roc/eleventh/tab1.pdf