Environment and Breast Cancer: Science Review
AboutCancer studies: Mammary gland tumors
Originating list
The list(s) or database(s) in which the chemical was identified as showing an
increase in mammary gland tumors. CPDB: Carcinogenic Potency Database, IARC:
International Agency for Research on Chemicals Monographs on the Evaluation of
Carcinogenic Risk of Chemicals to Man summaries, NTP TR: National Toxicology Program
(NTP) Technical Reports, NTP 11ROC: NTP 11th Report on Carcinogens, CCRIS: Chemical
Carcinogenesis Research Information Service.
Carcinogenicity Potency Database
Mammary gland tumor summary
A summary of findings related to mammary gland tumors, most
often excerpted from IARC Monographs or the NTP 11th ROC, and, in some cases,
supplemented by our evaluation of individual studies and reviews, is available for the priority
chemicals and 67 others.
One study reported increased malignant mammary tumors in female rats.
Citations to review sources and individual studies reporting mammary gland tumors are listed below.
Citation
Source Type
Notes
International Agency for Research on Cancer, Monographs on the evaluation of carcinogenic risk of chemicals to man.VOL.: 24 (1980) (p. 135) Phenacetin. Summary of Data Reported and Evaluation.
Review
International Agency for Research on Cancer, Monographs on the evaluation of carcinogenic risk of chemicals to man.VOL.: Supplement 7 (1987) (p. 310) Phenacetin and Analgesic mixtures Containing Phenacetin. Summary of Data Reported and Evaluation.
Review
Carcinogenic Potency Database 2005. Gold LS ST, Manley NB, Garfinkel GB, Ames BN. Summary Table by Chemical of Carcinogenicity Results in CPDB on 1485 Chemicals. 2005
Review
National Toxicology Program 11th Report on Carcinogens. Phenacetin and Analgesic mixtures Containing Phenacetin
Review
Johansson S, Angervall L. Urothelial changes of the renal papillae in Sprague-Dawley rats induced by long term feeding of phenacetin. Acta Pathol Microbiol Scand [A] 1976;84(5):375-83.
Primary Literature
Isaka H, Yoshii H, Otsuji A, Koike M, Nagai Y, Koura M, et al. Tumors of Sprague-Dawley rats induced by long-term feeding of phenacetin. Gann 1979;70(1):29-36.
Primary Literature
Johansson SL. Carcinogenicity of analgesics: long-term treatment of Sprague-Dawley rats with phenacetin, phenazone, caffeine and paracetamol (acetamidophen). Int J Cancer 1981;27(4):521-9.
Primary Literature
Kunze E, Woltjen HH, Hartmann B, Engelhardt W. Animal experiments regarding a possible carcinogenic effect of phenacetin on the resting and proliferating urothelium stimulated by cyclophosphamide. J Cancer Res Clin Oncol 1983;105(1):38-47.
Primary Literature
Macklin AW, Szot RJ. Eighteen month oral study of aspirin, phenacetin and caffeine, in C57Bl/6 mice. Drug Chem Toxicol 1980;3(2):135-63.
Primary Literature
Nakanishi K, Kurata Y, Oshima M, Fukushima S, Ito N. Carcinogenicity of phenacetin: long-term feeding study in B6c3f1 mice. Int J Cancer 1982;29(4):439-44.
Primary Literature
Johansson S, Angervall L. Urothelial changes of the renal papillae in Sprague-Dawley rats induced by long term feeding of phenacetin. Acta Pathol Microbiol Scand [A]. 1976 Sep;84(5):375-83.
Primary Literature
National Toxicology Program 11th Report on Carcinogens, Table 1. Chemicals nominated to the National Toxicology Program for in-depth toxicological evaluation for carcinogenesis testing in fiscal years 1988-2003.
Review