Environment and Breast Cancer: Science Review
Cancer studies: Mammary gland tumors
The list(s) or database(s) in which the chemical was identified as showing an increase in mammary gland tumors. CPDB: Carcinogenic Potency Database, IARC: International Agency for Research on Chemicals Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man summaries, NTP TR: National Toxicology Program (NTP) Technical Reports, NTP 11ROC: NTP 11th Report on Carcinogens, CCRIS: Chemical Carcinogenesis Research Information Service.IARC Monographs, National Toxicology Program 11th Report on Carcinogens, Chemical Carcinogenesis Research Information System
Mammary gland tumor summary
A summary of findings related to mammary gland tumors, most often excerpted from IARC Monographs or the NTP 11th ROC, and, in some cases, supplemented by our evaluation of individual studies and reviews, is available for the priority chemicals and 67 others.NTP 11ROC: Intraperitoneal injections of 4-nitropyrene caused an increased incidence of mammary adenocarcinomas in female rats. When administered by subcutaneous injections, 4-nitropyrene induced sarcomas at the injection site, and increased incidences of mammary adenocarcinomas in female rats. In two studies, female rats receiving mammary gland injections of 4-nitropyrene showed an increased incidence of mammary tumors.
Citations to review sources and individual studies reporting mammary gland tumors are listed below.
International Agency for Research on Cancer, Monographs on the evaluation of carcinogenic risk of chemicals to man.VOL.: 46 (1989) (p. 367) 4-Nitropyrene.
Carcinogenic Potency Database 2005. Gold LS ST, Manley NB, Garfinkel GB, Ames BN. Summary Table by Chemical of Carcinogenicity Results in CPDB on 1485 Chemicals. 2005
National Toxicology Program 11th Report on Carcinogens. Nitroarenes
Imaida K, Hirose M, Tay L, Lee MS, Wang CY, King CM. Comparative carcinogenicities of 1-, 2-, and 4-nitropyrene and structurally related compounds in the female CD rat. Cancer Res 1991;51(11):2902-7
Imaida K, Lee MS, Land SJ, Wang CY, King CM. Carcinogenicity of nitropyrenes in the newborn female rat. Carcinogenesis 1995;16(12):3027-30.
El-Bayoumy, K., A. Rivenson, P. Upadhyaya, Y. H. Chae and S. S. Hecht. 1993. Induction of mammary cancer by 6-nitrochrysene in female CD rats. Cancer Res 53(16): 3719-22.
King CM. Metabolism and biological effects of nitropyrene and related. Res Rep Health Eff Inst 1988(16):1-22.
National Toxicology Program 11th Report on Carcinogens, Table 1. Chemicals nominated to the National Toxicology Program for in-depth toxicological evaluation for carcinogenesis testing in fiscal years 1988-2003.