Environment and Breast Cancer: Science Review

Overview    |    Publications    |    Epidemiology Reviews Database    |    Mammary Carcinogens Review Database

Search the Mammary Carcinogens Reviews Database
About
Browse
Search
Key References
Abbreviations
 

7,12-dimethylbenz[a]anthracene
CAS RN 57-97-6

Chemical Summary
Exposure and Risk Assessment
Cancer Studies
 


Cancer studies: Mammary gland tumors
Print this page
Originating list
The list(s) or database(s) in which the chemical was identified as showing an increase in mammary gland tumors. CPDB: Carcinogenic Potency Database, IARC: International Agency for Research on Chemicals Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man summaries, NTP TR: National Toxicology Program (NTP) Technical Reports, NTP 11ROC: NTP 11th Report on Carcinogens, CCRIS: Chemical Carcinogenesis Research Information Service.
Chemical Carcinogenesis Research Information System
Mammary gland tumor summary
A summary of findings related to mammary gland tumors, most often excerpted from IARC Monographs or the NTP 11th ROC, and, in some cases, supplemented by our evaluation of individual studies and reviews, is available for the priority chemicals and 67 others.
NTP 11ROC: From a section on multiple PAH chemicals: Female mice injected subcutaneously with progesterone showed decreased latent periods for the induction of mammary tumors by 3-methylcholanthrene. Rats receiving subcutaneous or intramuscular injections of progesterone had decreased latent periods and/or increased incidences of mammary tumors induced by oral administration of 3-methylcholanthrene or 7,12-dimethylbenz[a]anthracene, but only when the known carcinogens were administered first. An increased incidence of mammary tumors was induced in female rats fed 2-acetylaminofluorene in the diet and injected intramuscularly with progesterone. Newborn female rats receiving a subcutaneous injection of progesterone and a subsequent intragastric instillation of 7,12-dimethylbenz[a]anthracene developed increased incidences of mammary adenocarcinomas.
Citations to review sources and individual studies reporting mammary gland tumors are listed below.
Citation
Source Type
Notes
National Library of Medicine. (CCRIS) Chemical Carcinogenesis Research Information System. [cited 2005 September 30]
Review
40 total references. 13 references for mammary tumors. 9 mammary tumors references from Publication 149 (see end). 4 mammary tumors original references. -TSUBURA,A, SENZAKI,H, SHIKATA,N, OISHI,Y AND MORII,S; INDUCTION OF TUMORS IN THE JAPANESE HOUSE MUSK SHREW, SUNCUS MURINIS (INSECTIVORA), BY DIMETHYLBENZ[A]ANTHRACENE; CARCINOGENESIS 12(8):1433-1436, 1991 -CAVALIERI,EL, HIGGINBOTHAM,S, RAMAKRISHNA,NVS, DEVANESAN,PD, TODOROVIC,R, ROGAN,EG AND SALMASI,S; COMPARATIVE DOSE-RESPONSE TUMORIGENICITY STUDIES OF DIBENZO[A,L]PYRENE VERSUS 7,12-DIMETHYLBENZ[A]ANTHRACENE, BENZO[A]PYRENE AND TWO DIBENZO[A]PYRENE DIHYDRODIOLS IN MOUSE SKIN AND RAT MAMMARY GLAND; CARCINOGENESIS 12(10):1939-1944, 1991 -TERADA,S, UCHIDE,K, SUZUKI,N, AKASOFU,K AND NISHIDA,E; INDUCTION OF DUCTAL CARCINOMAS BY INTRADUCTAL ADMINISTRATION OF 7,12-DIMETHYLBENZ[A]ANTHRACENE IN WISTAR RATS; BREAST CANCER RES. TREAT. 34(1):35-43, 1995 -QING,WG, CONTI,CJ, LABATE,M, JOHNSTON,D, SLAGA,TJ AND MACLEOD,MC; INDUCTION OF MAMMARY CANCER AND LYMPHOMA BY MULTIPLE, LOW ORAL DOSES OF 7,12-DIMETHYLBENZ[A]ANTHRACENE IN SENCAR MICE; CARCINOGENESIS 18(3):553-559, 1997 -National Institutes of Health; National Cancer Institute. Survey of Compounds which have been tested for Carcinogenic Activity: Formerly US Public Health Service Publication No. 149 [CD-ROM]. In: National Institutes of Health; National Cancer Institute; 2003.
http://toxnet.nlm.nih.gov/cgi-bin/sis/htmlgen?CCRIS
National Toxicology Program 11th Report on Carcinogens, Table 1. Chemicals nominated to the National Toxicology Program for in-depth toxicological evaluation for carcinogenesis testing in fiscal years 1988-2003.
Review
Not nominated for NTP testing in 1998-2003.
http://ntp.niehs.nih.gov/ntp/roc/eleventh/tab1.pdf