Environment and Breast Cancer: Science Review

Overview    |    Publications    |    Epidemiology Reviews Database    |    Mammary Carcinogens Review Database

Search the Mammary Carcinogens Reviews Database
About
Browse
Search
Key References
Abbreviations
 

progesterone
CAS RN 57-83-0

Chemical Summary
Exposure and Risk Assessment
Cancer Studies
 


Cancer studies: Mammary gland tumors
Print this page
Originating list
The list(s) or database(s) in which the chemical was identified as showing an increase in mammary gland tumors. CPDB: Carcinogenic Potency Database, IARC: International Agency for Research on Chemicals Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man summaries, NTP TR: National Toxicology Program (NTP) Technical Reports, NTP 11ROC: NTP 11th Report on Carcinogens, CCRIS: Chemical Carcinogenesis Research Information Service.
IARC Monographs, Chemical Carcinogenesis Research Information System
Mammary gland tumor summary
A summary of findings related to mammary gland tumors, most often excerpted from IARC Monographs or the NTP 11th ROC, and, in some cases, supplemented by our evaluation of individual studies and reviews, is available for the priority chemicals and 67 others.
NTP 11th ROC: When progesterone was implanted subcutaneously, mammary carcinomas were induced at a significantly earlier age and at a higher incidence in female mice. Subcutaneous injections of progesterone induced increased incidence of mammary tumors in adult female mice. Female mice injected subcutaneously with progesterone showed decreased latent periods for the induction of mammary tumors by 3-methylcholanthrene. Newborn female rats receiving a subcutaneous injection of progesterone and a subsequent intragastric instillation of 7,12-dimethylbenz[a]anthracene developed increased incidence of mammary adenocarcinomas.
Citations to review sources and individual studies reporting mammary gland tumors are listed below.
Citation
Source Type
Notes
International Agency for Research on Cancer, Monographs on the evaluation of carcinogenic risk of chemicals to man.VOL.: Supplement 7 (1987) (p. 289) Progestins. Summary of Data Reported and Evaluation.
Review
When tested by subcutaneous and intramuscular injection and by subcutaneous implantation in mice, increased incidence of mammary tumors in mice. Neonatal treatment with progesterone increased mammary tumorigenesis in female mice (IARC 1979).
http://monographs.iarc.fr/ENG/Monographs/suppl7/suppl7.pd...
National Toxicology Program 11th Report on Carcinogens. Progesterone
Review
When progesterone was implanted subcutaneously, mammary carcinomas were induced at a significantly earlier age and at a higher incidence in female mice. Subcutaneous injections of progesterone induced increased incidences of mammary tumors in adult female mice. Long-term subcutaneous injections in female dogs induced marked mammary hyperplasia, and some fibroadenomatous nodules of the mammary gland (IARC 1974, 1979, 1982).
http://ntp.niehs.nih.gov/ntp/roc/eleventh/profiles/s152pr...
National Toxicology Program 11th Report on Carcinogens, Table 1. Chemicals nominated to the National Toxicology Program for in-depth toxicological evaluation for carcinogenesis testing in fiscal years 1988-2003.
Review
Not nominated for NTP testing in 1998-2003.
http://ntp.niehs.nih.gov/ntp/roc/eleventh/tab1.pdf