Environment and Breast Cancer: Science Review

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C.I. Basic Red 9 monohydrochloride
CAS RN 569-61-9

Cancer studies: Mammary gland tumors
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Originating list
The list(s) or database(s) in which the chemical was identified as showing an increase in mammary gland tumors. CPDB: Carcinogenic Potency Database, IARC: International Agency for Research on Chemicals Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man summaries, NTP TR: National Toxicology Program (NTP) Technical Reports, NTP 11ROC: NTP 11th Report on Carcinogens, CCRIS: Chemical Carcinogenesis Research Information Service.
National Toxicology Program studies, Chemical Carcinogenesis Research Information System
Mammary gland tumor summary
A summary of findings related to mammary gland tumors, most often excerpted from IARC Monographs or the NTP 11th ROC, and, in some cases, supplemented by our evaluation of individual studies and reviews, is available for the priority chemicals and 67 others.
NTP 11th ROC: Increased incidence of mammary gland tumors in female rats may have been related to exposure to the compound.
Citations to review sources and individual studies reporting mammary gland tumors are listed below.
Source Type
International Agency for Research on Cancer, Monographs on the evaluation of carcinogenic risk of chemicals to man.VOL.: 57 (1993) (p. 215) Magenta and CI Basic Red 9. Summary of Data Reported and Evaluation.
Does not mention mammary tumors.
Carcinogenic Potency Database 2005. Gold LS ST, Manley NB, Garfinkel GB, Ames BN. Summary Table by Chemical of Carcinogenicity Results in CPDB on 1485 Chemicals. 2005
One of three studies reports mammary tumors: NTP TR285. Two studies did not report mammary tumors: Green 1979 and Ketkar 1982.
National Toxicology Program 11th Report on Carcinogens. C.I. Basic Red Monohydrochloride
Increased incidences of mammary gland tumors in female rats (NTP 1986).
Green U, Holste J, Spikermann AR. A comparative study of the chronic effects of magenta, paramagenta, and phenyl-beta-naphthylamine in Syrian golden hamsters. J Cancer Res Clin Oncol 1979;95(1):51-5.
Primary Literature
A study listed by CPDB 2005 that did not report mammary tumors.
Ketkar MB, Mohr U. The chronic effects of magenta, paramagenta and phenyl-beta-naphthylamine in rats after intragastric administration. Cancer Lett 1982;16(2):203-6.
Primary Literature
A study listed by CPDB 2005 that did not report mammary tumors.
National Toxicology Program Technical Report 285, 1986
Primary Literature
National Toxicology Program 11th Report on Carcinogens, Table 1. Chemicals nominated to the National Toxicology Program for in-depth toxicological evaluation for carcinogenesis testing in fiscal years 1988-2003.
Not nominated for NTP testing in 1998-2003.