Environment and Breast Cancer: Science Review

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Key References
Abbreviations
 

carbon tetrachloride
CAS RN 56-23-5

Chemical Summary
Exposure and Risk Assessment
Cancer Studies
 


Cancer studies: Mammary gland tumors
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Originating list
The list(s) or database(s) in which the chemical was identified as showing an increase in mammary gland tumors. CPDB: Carcinogenic Potency Database, IARC: International Agency for Research on Chemicals Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man summaries, NTP TR: National Toxicology Program (NTP) Technical Reports, NTP 11ROC: NTP 11th Report on Carcinogens, CCRIS: Chemical Carcinogenesis Research Information Service.
Carcinogenicity Potency Database, IARC Monographs, National Toxicology Program 11th Report on Carcinogens
Mammary gland tumor summary
A summary of findings related to mammary gland tumors, most often excerpted from IARC Monographs or the NTP 11th ROC, and, in some cases, supplemented by our evaluation of individual studies and reviews, is available for the priority chemicals and 67 others.
NTP 11th ROC: When administered by subcutaneous injection, carbon tetrachloride induced mammary adenocarcinomas and fibroadenomas in female rats.
Citations to review sources and individual studies reporting mammary gland tumors are listed below.
Citation
Source Type
Notes
International Agency for Research on Cancer, Monographs on the evaluation of carcinogenic risk of chemicals to man.VOL.: 20 (1979) (p. 371) Carbon Tetrachloride.
Review
Produced mammary neoplasms in rats following subcutaneous injection: Alpert 1972 (in Russian, won't review.)
http://monographs.iarc.fr/ENG/Monographs/vol20/volume20.p...
International Agency for Research on Cancer, Monographs on the evaluation of carcinogenic risk of chemicals to man.VOL.: 71 (1999) (p. 401) Carbon Tetrachloride.
Review
Produced mammary neoplasms in rats following subcutaneous injection, only reference is IARC 1979 v.20, p.371.
http://monographs.iarc.fr/ENG/Monographs/vol71/volume71.p...
Carcinogenic Potency Database 2005. Gold LS ST, Manley NB, Garfinkel GB, Ames BN. Summary Table by Chemical of Carcinogenicity Results in CPDB on 1485 Chemicals. 2005
Review
One of two studies reports mammary tumors: Tourkevitch 1964. One study did not report mammary tumors: Weisburger 1977.
http://potency.berkeley.edu/pdfs/ChemicalTable.pdfpotency...
National Toxicology Program 11th Report on Carcinogens.
Review
When administered by subcutaneous injection, induced mammary adenocarcinomas and fibroadenomas in female rats (IARC 1972, 1979, 1982, 1987, 1999).
http://ntp.niehs.nih.gov/ntp/roc/eleventh/profiles/s029ca...
Weisburger EK. Carcinogenicity studies on halogenated hydrocarbons. Environ Health Perspect 1977;21:7-16.
Primary Literature
A study listed by CPDB 2005 that did not report mammary tumors.
Tourkevitch NM, Gorevaia AN, Kounitsa LK, Mao LS. [Development Of Mammary Gland Tumors In Rats In Case Of Endocrine Regulation Disorders Induced By Various Means.]. Acta Unio Int Contra Cancrum 1964;20:1446-9.
Primary Literature
In French. Abstract not available in PubMed.
Alpert AE, Arkhangelsky AV, Lunts AM, Panina NP. Experimental hepatopathies and carcinoma of the breast in rats (Russ.). Bjull. Eksp. Biol. Med. 1972;74:78-81.
Primary Literature
From IARC, positive for mammary tumors. In Russian won't review.
National Toxicology Program 11th Report on Carcinogens, Table 1. Chemicals nominated to the National Toxicology Program for in-depth toxicological evaluation for carcinogenesis testing in fiscal years 1988-2003.
Review
Nominated by the State of California EPA in 1995. Rationale:" Data gaps need to be filled for setting scientifically based acute and chronic non-cancer reference exposure levels for use in human and environmental risk assessments." Current NTP Status: No additional testing.
http://ntp.niehs.nih.gov/ntp/roc/eleventh/tab1.pdf