Environment and Breast Cancer: Science Review
Cancer studies: Mammary gland tumors
The list(s) or database(s) in which the chemical was identified as showing an increase in mammary gland tumors. CPDB: Carcinogenic Potency Database, IARC: International Agency for Research on Chemicals Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man summaries, NTP TR: National Toxicology Program (NTP) Technical Reports, NTP 11ROC: NTP 11th Report on Carcinogens, CCRIS: Chemical Carcinogenesis Research Information Service.Carcinogenicity Potency Database, IARC Monographs, National Toxicology Program 11th Report on Carcinogens
Mammary gland tumor summary
A summary of findings related to mammary gland tumors, most often excerpted from IARC Monographs or the NTP 11th ROC, and, in some cases, supplemented by our evaluation of individual studies and reviews, is available for the priority chemicals and 67 others.NTP 11th ROC: When administered by subcutaneous injection, carbon tetrachloride induced mammary adenocarcinomas and fibroadenomas in female rats.
Citations to review sources and individual studies reporting mammary gland tumors are listed below.
International Agency for Research on Cancer, Monographs on the evaluation of carcinogenic risk of chemicals to man.VOL.: 20 (1979) (p. 371) Carbon Tetrachloride.
International Agency for Research on Cancer, Monographs on the evaluation of carcinogenic risk of chemicals to man.VOL.: 71 (1999) (p. 401) Carbon Tetrachloride.
Carcinogenic Potency Database 2005. Gold LS ST, Manley NB, Garfinkel GB, Ames BN. Summary Table by Chemical of Carcinogenicity Results in CPDB on 1485 Chemicals. 2005
National Toxicology Program 11th Report on Carcinogens.
Weisburger EK. Carcinogenicity studies on halogenated hydrocarbons. Environ Health Perspect 1977;21:7-16.
Tourkevitch NM, Gorevaia AN, Kounitsa LK, Mao LS. [Development Of Mammary Gland Tumors In Rats In Case Of Endocrine Regulation Disorders Induced By Various Means.]. Acta Unio Int Contra Cancrum 1964;20:1446-9.
Alpert AE, Arkhangelsky AV, Lunts AM, Panina NP. Experimental hepatopathies and carcinoma of the breast in rats (Russ.). Bjull. Eksp. Biol. Med. 1972;74:78-81.
National Toxicology Program 11th Report on Carcinogens, Table 1. Chemicals nominated to the National Toxicology Program for in-depth toxicological evaluation for carcinogenesis testing in fiscal years 1988-2003.