Environment and Breast Cancer: Science Review
Cancer studies: Mammary gland tumors
The list(s) or database(s) in which the chemical was identified as showing an increase in mammary gland tumors. CPDB: Carcinogenic Potency Database, IARC: International Agency for Research on Chemicals Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man summaries, NTP TR: National Toxicology Program (NTP) Technical Reports, NTP 11ROC: NTP 11th Report on Carcinogens, CCRIS: Chemical Carcinogenesis Research Information Service.Carcinogenicity Potency Database, IARC Monographs, National Toxicology Program 11th Report on Carcinogens, Chemical Carcinogenesis Research Information System
Mammary gland tumor summary
A summary of findings related to mammary gland tumors, most often excerpted from IARC Monographs or the NTP 11th ROC, and, in some cases, supplemented by our evaluation of individual studies and reviews, is available for the priority chemicals and 67 others.In studies listed in CPDB and NTP 11th ROC, five of eight studies report increased benign and/or malignant mammary tumors from dosing. NTP 11th ROC: When administered by subcutaneous injections, 1-nitropyrene induced mammary tumors (including adenocarcinomas) in female rats. A study in female rats injected intraperitoneally with 1-nitropyrene showed increased mammary tumors; a second intraperitoneal study demonstrated a nonstatistically significant increase in mammary tumors. Mammary gland tumors were also increased following oral administration of 1-nitropyrene to female rats.
Citations to review sources and individual studies reporting mammary gland tumors are listed below.
International Agency for Research on Cancer, Monographs on the evaluation of carcinogenic risk of chemicals to man.VOL.: 46 (1989) (p. 321) 1-Nitropyrene.
Carcinogenic Potency Database 2005. Gold LS ST, Manley NB, Garfinkel GB, Ames BN. Summary Table by Chemical of Carcinogenicity Results in CPDB on 1485 Chemicals. 2005
National Toxicology Program 11th Report on Carcinogens. Nitroarenes (Selected)
el-Bayoumy K, Chae YH, Upadhyaya P, Rivenson A, Kurtzke C, Reddy B, et al. Comparative tumorigenicity of benzo[a]pyrene, 1-nitropyrene and 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine administered by gavage to female CD rats. Carcinogenesis 1995;16(2):431-4.
el-Bayoumy K, Rivenson A, Johnson B, DiBello J, Little P, Hecht SS. Comparative tumorigenicity of 1-nitropyrene, 1-nitrosopyrene, and 1-aminopyrene administered by gavage to Sprague-Dawley rats. Cancer Res 1988;48(15):4256-60.
Hirose M, Lee MS, Wang CY, King CM. Induction of rat mammary gland tumors by 1-nitropyrene, a recently recognized environmental mutagen. Cancer Res 1984;44(3):1158-62
Imaida K, Hirose M, Tay L, Lee MS, Wang CY, King CM. Comparative carcinogenicities of 1-, 2-, and 4-nitropyrene and structurally related compounds in the female CD rat. Cancer Res 1991;51(11):2902-7.
Imaida K, Lee MS, Land SJ, Wang CY, King CM. Carcinogenicity of nitropyrenes in the newborn female rat. Carcinogenesis 1995;16(12):3027-30.
Odagiri Y, Adachi S, Katayama H, Matsushita H, Takemoto K. Carcinogenic effects of a mixture of nitropyrenes in F344 rats following its repeated oral administrations. Dev Toxicol Environ Sci 1986;13:291-307
El-Bayoumy K, Hecht SS, Sackl T, Stoner GD. Tumorigenicity and metabolism of 1-nitropyrene in A/J mice. Carcinogenesis 1984;5(11):1449-52.
El-Bayoumy K, Hecht SS. Identification and mutagenicity of metabolites of 1-nitropyrene formed by rat liver. Cancer Res 1983;43(7):3132-7.
Moon RC, Rao KV, Detrisac CJ. Respiratory carcinogenesis of nitroaromatics. Res Rep Health Eff Inst 1990(32):1-29.
Wislocki PG, Bagan ES, Lu AY, Dooley KL, Fu PP, Han-Hsu H, et al. Tumorigenicity of nitrated derivatives of pyrene, benz[a]anthracene, chrysene and benzo[a]pyrene in the newborn mouse assay. Carcinogenesis 1986;7(8):1317-22.
King CM. Metabolism and biological effects of nitropyrene and related. Res Rep Health Eff Inst 1988(16):1-22.