Environment and Breast Cancer: Science Review

Overview    |    Publications    |    Epidemiology Reviews Database    |    Mammary Carcinogens Review Database

Search the Mammary Carcinogens Reviews Database
About
Browse
Search
Key References
Abbreviations
 

1-nitropyrene
CAS RN 5522-43-0

Chemical Summary
Exposure and Risk Assessment
Cancer Studies
 


Cancer studies: Mammary gland tumors
Print this page
Originating list
The list(s) or database(s) in which the chemical was identified as showing an increase in mammary gland tumors. CPDB: Carcinogenic Potency Database, IARC: International Agency for Research on Chemicals Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man summaries, NTP TR: National Toxicology Program (NTP) Technical Reports, NTP 11ROC: NTP 11th Report on Carcinogens, CCRIS: Chemical Carcinogenesis Research Information Service.
Carcinogenicity Potency Database, IARC Monographs, National Toxicology Program 11th Report on Carcinogens, Chemical Carcinogenesis Research Information System
Mammary gland tumor summary
A summary of findings related to mammary gland tumors, most often excerpted from IARC Monographs or the NTP 11th ROC, and, in some cases, supplemented by our evaluation of individual studies and reviews, is available for the priority chemicals and 67 others.
In studies listed in CPDB and NTP 11th ROC, five of eight studies report increased benign and/or malignant mammary tumors from dosing. NTP 11th ROC: When administered by subcutaneous injections, 1-nitropyrene induced mammary tumors (including adenocarcinomas) in female rats. A study in female rats injected intraperitoneally with 1-nitropyrene showed increased mammary tumors; a second intraperitoneal study demonstrated a nonstatistically significant increase in mammary tumors. Mammary gland tumors were also increased following oral administration of 1-nitropyrene to female rats.
Citations to review sources and individual studies reporting mammary gland tumors are listed below.
Citation
Source Type
Notes
International Agency for Research on Cancer, Monographs on the evaluation of carcinogenic risk of chemicals to man.VOL.: 46 (1989) (p. 321) 1-Nitropyrene.
Review
subcutaneous injection in newborn rats increased mammary tumors (in 1 of 3: Hirose 1984), intraperitoneal injection on weanling rats increased mammary tumors (1 of 2: King 1988). gavage rat increased mammary tumors Odagiri 1986 [The Working Group noted the presence of dinitropyrene impurities and could not ascertain their potential effect on the outcome of the experiment.] King CM 1988 [The Working Group noted the short furation of both treatmenta nd observation- for a non mammary tumors exp.][newborns receiving subcut inj- not different from controls= The Working Group noted the high and variable spontaneous incidence of mammary tumors in the CD rats and the unusually low incidence of leukemia in control Fischer 344 rats.] [last study listed, mammary tumors reported- The Working Group noted the inconsisten findings and the variations in the incidences of mammary tumours in controls.]
http://monographs.iarc.fr/ENG/Monographs/vol46/volume46.p...
Carcinogenic Potency Database 2005. Gold LS ST, Manley NB, Garfinkel GB, Ames BN. Summary Table by Chemical of Carcinogenicity Results in CPDB on 1485 Chemicals. 2005
Review
1 of 1 reference showed mammary tumors: Odagiri 1986.
http://potency.berkeley.edu/pdfs/ChemicalTable.pdfpotency...
National Toxicology Program 11th Report on Carcinogens. Nitroarenes (Selected)
Review
By subcut inj, increased mammary tumors in female rats: Hirose 1984 and Imaida 1995. Female rats by ip increased mammary tumors in 1 of 2 studies (IARC 1989, Imaida 1991).Oral administration increased mammary tumors in female rats (El-Bayoumy 1988, 1995). Studies that are not noted for mammary tumors: El-Bayoumy and Hecht 1983, El-Bayoumy 1984, Wislocki 1986 (possibly males only), Moon 1990 (intratracheal admin in carbon black particle-so possibly only lung endpoint monitored)
http://ntp.niehs.nih.gov/ntp/roc/eleventh/profiles/s121ni...
el-Bayoumy K, Chae YH, Upadhyaya P, Rivenson A, Kurtzke C, Reddy B, et al. Comparative tumorigenicity of benzo[a]pyrene, 1-nitropyrene and 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine administered by gavage to female CD rats. Carcinogenesis 1995;16(2):431-4.
Primary Literature

experimental details
Increase in benign mammary tumors. Only one dose level. Fibroadenoma 0/30, 10/30; Desmoplastic adenoma 8/30, 15/30 (different breakdown than other articles); Adenoma 2/30, 7/30
el-Bayoumy K, Rivenson A, Johnson B, DiBello J, Little P, Hecht SS. Comparative tumorigenicity of 1-nitropyrene, 1-nitrosopyrene, and 1-aminopyrene administered by gavage to Sprague-Dawley rats. Cancer Res 1988;48(15):4256-60.
Primary Literature

experimental details
Increased malignant mammary tumors in female rats: 1/31, 14/33, 15/24 adenocarcinoma. 1/wk for 16 wks, 250 umol/kg body weight; 40.5 umol/ml trioctanoin (800 umol total), 100 umol/kg body weight; 16.2 umol/ml trioctanoin (320 umol total)
Hirose M, Lee MS, Wang CY, King CM. Induction of rat mammary gland tumors by 1-nitropyrene, a recently recognized environmental mutagen. Cancer Res 1984;44(3):1158-62
Primary Literature

experimental details
Mammary tumors increased by dose in female rats. 0, 50, 100 umol/kg body weight, 1/wk for 8 wks to rats began within 24 hrs of birth. Females: adenocarcinoma 0/31, 3/31, 10/32 Females: fibroadenoma 1/31, 5/31, 7/32
Imaida K, Hirose M, Tay L, Lee MS, Wang CY, King CM. Comparative carcinogenicities of 1-, 2-, and 4-nitropyrene and structurally related compounds in the female CD rat. Cancer Res 1991;51(11):2902-7.
Primary Literature

experimental details
Increased mammary tumors with treatment: ip or sc, 100 umol/kg body weight, 1/wk for 4 wks. Direct treatment to mammary pads did not cause an increase in mammary tumors. 4-nitropyrene more potent in these experiments. ip 9/30, 14/29 fibroadenoma (not stat sig) sc 8/30, 15/29 fibroadenoma (stat sig) ip 2/30, 8/29 adenocarcinoma (stat sig) sc 4/30, 6/29 adenocarcinoma (not stat sig)
Imaida K, Lee MS, Land SJ, Wang CY, King CM. Carcinogenicity of nitropyrenes in the newborn female rat. Carcinogenesis 1995;16(12):3027-30.
Primary Literature

experimental details
Increased malignant mammary tumors in rats. 10 umol/kg experiment: adenocarcinoma 1/40, 10/49 (stat sig) 100 umol/kg experiment, CD rats: adenocarcinoma 3/47, 10/63 F344 rats were not as sensitive to the effects as were CD rats.
Odagiri Y, Adachi S, Katayama H, Matsushita H, Takemoto K. Carcinogenic effects of a mixture of nitropyrenes in F344 rats following its repeated oral administrations. Dev Toxicol Environ Sci 1986;13:291-307
Primary Literature

experimental details
Increase in benign and malignant mammary tumors seen. 0, 5, 10, 20 mg/kg body weight; Mix 4/30, 13/40, 21/40, 22/46.
El-Bayoumy K, Hecht SS, Sackl T, Stoner GD. Tumorigenicity and metabolism of 1-nitropyrene in A/J mice. Carcinogenesis 1984;5(11):1449-52.
Primary Literature
A study listed by CPDB 2005 that did not report mammary tumors. One time ip injection of large amounts of nitropyrene: 0.71 mmol/kg, 2.14 mmol/kg, or 6.44 mmol/kg. Abstract notes liver and lung tumors, and it is unclear whether other endpoints were examined.
El-Bayoumy K, Hecht SS. Identification and mutagenicity of metabolites of 1-nitropyrene formed by rat liver. Cancer Res 1983;43(7):3132-7.
Primary Literature
A study listed by CPDB 2005 that did not report mammary tumors. Not an animal study. Looked at metabolites of 1-nitropyrene formed by rat liver and tested mutagenicity on S. typhimurium TA 100.
Moon RC, Rao KV, Detrisac CJ. Respiratory carcinogenesis of nitroaromatics. Res Rep Health Eff Inst 1990(32):1-29.
Primary Literature
A study listed by CPDB 2005 that did not report mammary tumors. Authors were using a respiratory-carcinogenesis model, so if mammary tumors had occurred they may have been unlikely to be noted.
Wislocki PG, Bagan ES, Lu AY, Dooley KL, Fu PP, Han-Hsu H, et al. Tumorigenicity of nitrated derivatives of pyrene, benz[a]anthracene, chrysene and benzo[a]pyrene in the newborn mouse assay. Carcinogenesis 1986;7(8):1317-22.
Primary Literature
A study listed by CPDB 2005 that did not report mammary tumors. Total doses were lower than other studies: 700 and 2800 nmol per mouse, at least 100x less than other studies.
King CM. Metabolism and biological effects of nitropyrene and related. Res Rep Health Eff Inst 1988(16):1-22.
Primary Literature
From IARC, positive for mammary tumors. Review in progress.