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Key References
Abbreviations
 

dibenz[a,h]anthracene
CAS RN 53-70-3

Chemical Summary
Exposure and Risk Assessment
Cancer Studies
 


Cancer studies: Mammary gland tumors
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Originating list
The list(s) or database(s) in which the chemical was identified as showing an increase in mammary gland tumors. CPDB: Carcinogenic Potency Database, IARC: International Agency for Research on Chemicals Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man summaries, NTP TR: National Toxicology Program (NTP) Technical Reports, NTP 11ROC: NTP 11th Report on Carcinogens, CCRIS: Chemical Carcinogenesis Research Information Service.
National Toxicology Program 11th Report on Carcinogens
Mammary gland tumor summary
A summary of findings related to mammary gland tumors, most often excerpted from IARC Monographs or the NTP 11th ROC, and, in some cases, supplemented by our evaluation of individual studies and reviews, is available for the priority chemicals and 67 others.
NTP 11th ROC: When administered as an olive oil emulsion in place of the drinking water, dibenz[a,h]anthracene induced mammary carcinomas in female mice.
Citations to review sources and individual studies reporting mammary gland tumors are listed below.
Citation
Source Type
Notes
International Agency for Research on Cancer, Monographs on the evaluation of carcinogenic risk of chemicals to man.VOL.: 3 (1973) (p. 178) Dibenz[a,h]anthracene.
Review
Increased mammary tumors in mice by gavage: Biancifiori and Caschera 1962. Increased mammary tumors in mice by dermal exposure: Ranadive and Karande 1963.
http://monographs.iarc.fr/ENG/Monographs/vol3/volume3.pdf...
International Agency for Research on Cancer, Monographs on the evaluation of carcinogenic risk of chemicals to man.VOL.: 32 (1983) (p. 299) Dibenz[a,h]anthracene.
Review
Does not mention mammary tumors. See vol. 3 below.
http://monographs.iarc.fr/ENG/Monographs/vol32/volume32.p...
Carcinogenic Potency Database 2005. Gold LS ST, Manley NB, Garfinkel GB, Ames BN. Summary Table by Chemical of Carcinogenicity Results in CPDB on 1485 Chemicals. 2005
Review
One of one study did not report mamary tumors: Snell 1962.
http://potency.berkeley.edu/pdfs/ChemicalTable.pdfpotency...
National Toxicology Program 11th Report on Carcinogens. Polycyclic Aromatic Hydrocarbons
Review
When administered as an olive oil emulsion in place of the drinking water, dibenz[a,h]anthracene induced mammary carcinomas in female mice (IARC 1973).
http://ntp.niehs.nih.gov/ntp/roc/eleventh/profiles/s150pa...
Snell KC, Stewart HL. Pulmonary adenomatosis induced in DBA/2 mice by oral administration of dibenz[a,h]-anthracene. J Natl Cancer Inst 1962;28:1043-51.
Primary Literature
A study listed by CPDB 2005 that did not report mammary tumors. Possible that they were only looking for lung tumors.
Biancifiori C, Caschera F. The relation between pseudopregnancy and the chemical induction by carcinogens of mammary and ovarian tumours in BALB/C mice. Br J Cancer 1962;16:722-30.
Primary Literature
From IARC, review postponed.
Ranadive KJ, Karande KA. Studies On 1,2:5,6-Dibenzanthracene Induced Mammary Carcinogenesis In Mice. Br J Cancer 1963;17:272-80.
Primary Literature
From IARC, review postponed.
National Toxicology Program 11th Report on Carcinogens, Table 1. Chemicals nominated to the National Toxicology Program for in-depth toxicological evaluation for carcinogenesis testing in fiscal years 1988-2003.
Review
Not nominated for NTP testing in 1998-2003.
http://ntp.niehs.nih.gov/ntp/roc/eleventh/tab1.pdf