Environment and Breast Cancer: Science Review

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CAS RN 51630-58-1

Cancer studies: Mammary gland tumors
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Originating list
The list(s) or database(s) in which the chemical was identified as showing an increase in mammary gland tumors. CPDB: Carcinogenic Potency Database, IARC: International Agency for Research on Chemicals Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man summaries, NTP TR: National Toxicology Program (NTP) Technical Reports, NTP 11ROC: NTP 11th Report on Carcinogens, CCRIS: Chemical Carcinogenesis Research Information Service.
IARC Monographs
Mammary gland tumor summary
A summary of findings related to mammary gland tumors, most often excerpted from IARC Monographs or the NTP 11th ROC, and, in some cases, supplemented by our evaluation of individual studies and reviews, is available for the priority chemicals and 67 others.
IARC 1991: When administered orally, there was an increased incidence of benign mammary tumors in female rats in one study.
Citations to review sources and individual studies reporting mammary gland tumors are listed below.
Source Type
International Agency for Research on Cancer, Monographs on the evaluation of carcinogenic risk of chemicals to man.VOL.: 53 (1991) (p. 309) Fenvalerate. Summary of Data Reported and Evaluation.
Administration by diet induced benign mammary tumors in female rats. [The Working Group noted the variable historical incidence of benign mammary tumors in this strain of rats]: Parker 1984.
Carcinogenic Potency Database 2005. Gold LS ST, Manley NB, Garfinkel GB, Ames BN. Summary Table by Chemical of Carcinogenicity Results in CPDB on 1485 Chemicals. 2005
One of three studies reports mammary tumors: Parker 1984. Two studies did not report mammary tumors: Parker 1983 and Cabral 1990.
Parker CM, Patterson DR, Van Gelder GA, Gordon EB, Valerio MG, Hall WC. Chronic toxicity and carcinogenicity evaluation of fenvalerate in rats. J Toxicol Environ Health 1984;13(1):83-97.
Primary Literature
Cabral JR, Galendo D. Carcinogenicity study of the pesticide fenvalerate in mice. Cancer Lett 1990;49(1):13-8.
Primary Literature
A study listed by CPDB 2005 that did not report mammary tumors.
Parker CM, McCullough CB, Gellatly JB, Johnston CD. Toxicologic and carcinogenic evaluation of Fenvalerate in the B6C3F1 mouse. Fundam Appl Toxicol 1983;3(2):114-20.
Primary Literature
A study listed by CPDB 2005 that did not report mammary tumors.
National Toxicology Program 11th Report on Carcinogens, Table 1. Chemicals nominated to the National Toxicology Program for in-depth toxicological evaluation for carcinogenesis testing in fiscal years 1988-2003.
Not nominated for NTP testing in 1998-2003.