Environment and Breast Cancer: Science Review
Cancer studies: Mammary gland tumors
The list(s) or database(s) in which the chemical was identified as showing an increase in mammary gland tumors. CPDB: Carcinogenic Potency Database, IARC: International Agency for Research on Chemicals Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man summaries, NTP TR: National Toxicology Program (NTP) Technical Reports, NTP 11ROC: NTP 11th Report on Carcinogens, CCRIS: Chemical Carcinogenesis Research Information Service.National Toxicology Program 11th Report on Carcinogens , Chemical Carcinogenesis Research Information System
Mammary gland tumor summary
A summary of findings related to mammary gland tumors, most often excerpted from IARC Monographs or the NTP 11th ROC, and, in some cases, supplemented by our evaluation of individual studies and reviews, is available for the priority chemicals and 67 others.NTP 11th ROC: When administered by gavage, benzo[a]pyrene induced mammary tumors in female rats. When administered by intraperitoneal injection, benzo[a]pyrene induced mammary carcinoma in rats.
Citations to review sources and individual studies reporting mammary gland tumors are listed below.
International Agency for Research on Cancer, Monographs on the evaluation of carcinogenic risk of chemicals to man.s. VOL.: 3 (1973) (p. 91)
Carcinogenic Potency Database 2005. Gold LS ST, Manley NB, Garfinkel GB, Ames BN. Summary Table by Chemical of Carcinogenicity Results in CPDB on 1485 Chemicals. 2005
National Toxicology Program 11th Report on Carcinogens, Polycyclic Aromatic Hydrocarbons, 15 Listings
el-Bayoumy K, Chae YH, Upadhyaya P, Rivenson A, Kurtzke C, Reddy B, et al. Comparative tumorigenicity of benzo[a]pyrene, 1-nitropyrene and 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine administered by gavage to female CD rats. Carcinogenesis 1995;16(2):431-4.
Brune H, Deutsch-Wenzel RP, Habs M, Ivankovic S, Schmahl D. Investigation of the tumorigenic response to benzo(a)pyrene in aqueous caffeine solution applied orally to Sprague-Dawley rats. J Cancer Res Clin Oncol 1981;102(2):153-7.
Chouroulinkov I, Gentil A, Guerin M. [Study of the carcinogenic action of orally administered 9, 10-dimethylbenzanthracene and 3,4-benzopyrene]. Bull Cancer 1967;54(1):67-78.
Griciute L. Investigation on the combined action of N-nitrosodiethylamine with other carcinogens. IARC Sci Publ 1980(31):813-23.
Horie A, Hohchi S, Kuratsune M. Carcinogenesis in the esophagus. II. Experimental production of esophageal cancer by administration of ethanolic solution of carcinogens. Gann 1965;56(5):429-41.
Huggins C, Yang NC. Induction and extinction of mammary cancer. A striking effect of hydrocarbons permits analysis of mechanisms of causes and cure of breast cancer. Science 1962;137:257-62.
Payne S. The pathological effects of the intraperitoneal injection of 3:4-benzpyrene into rats and mice. Br J Cancer 1958;12(1):65-74.
National Toxicology Program 11th Report on Carcinogens, Table 1. Chemicals nominated to the National Toxicology Program for in-depth toxicological evaluation for carcinogenesis testing in fiscal years 1988-2003.