Environment and Breast Cancer: Science Review

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Key References
Abbreviations
 

estradiol-17b
CAS RN 50-28-2

Chemical Summary
Exposure and Risk Assessment
Cancer Studies
 


Cancer studies: Mammary gland tumors
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Originating list
The list(s) or database(s) in which the chemical was identified as showing an increase in mammary gland tumors. CPDB: Carcinogenic Potency Database, IARC: International Agency for Research on Chemicals Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man summaries, NTP TR: National Toxicology Program (NTP) Technical Reports, NTP 11ROC: NTP 11th Report on Carcinogens, CCRIS: Chemical Carcinogenesis Research Information Service.
IARC Monographs, Chemical Carcinogenesis Research Information System
Mammary gland tumor summary
A summary of findings related to mammary gland tumors, most often excerpted from IARC Monographs or the NTP 11th ROC, and, in some cases, supplemented by our evaluation of individual studies and reviews, is available for the priority chemicals and 67 others.
Evidence of increased breast cancer in humans and increased mammary gland tumors in animals.
Citations to review sources and individual studies reporting mammary gland tumors are listed below.
Citation
Source Type
Notes
International Agency for Research on Cancer, Monographs on the evaluation of carcinogenic risk of chemicals to man.VOL.: Supplement 7 (1987) (p. 280) Oestrogens, Steroidal. Summary of Data Reported and Evaluation.
Review
Oral and subcutaneous administration in mice increased the incidences of mammary tumors. In rats, there was an increased incidence of mammary tumors after oral and subcutaneous administration. References: -IARC 1979 -Huseby, R.A. (1980) Demonstration of a direct carcinogenic effect of estradiol on Leydig cells of the mouse. Cancer Res., 40, 1006-1013 -Highman, B., Roth, S.I. & Greenman, D.L. (1981) Osseous changes and osteosarcomas in mice continuously fed diets containing diethylstilbestrol or 17b-estradiol. J. natl Cancer Inst., 67, 653-662 -Highman, B., Greenman, D.L., Norvell, M.J., Farmer, J. & Shellenberger, T.E. (1980) Neoplastic and preneoplastic lesions induced in female C3H mice by diets containing diethylstilbestrol or 17b-estradiol. J. environ. Pathol. Toxicol., 4, 81-95 -Nagasawa, H., Mori, T. & Nakajima, Y. (1980) Long-term effects of progesterone or diethylstilbestrol with or without estrogen after maturity on mammary tumorigenesis in mice. Eur. J. Cancer, 16, 1583-1589 -Inoh, A., Kamiya, K., Fujii, Y. & Yokoro, K. (1985) Protective effects of progesterone and tamoxifen in estrogen-induced mammary carcinogenesis in ovariectomized W/FU rats. Jpn. J. Cancer Res. (Gann), 76, 699-704
http://monographs.iarc.fr/ENG/Monographs/suppl7/suppl7.pd...
Carcinogenic Potency Database 2005. Gold LS ST, Manley NB, Garfinkel GB, Ames BN. Summary Table by Chemical of Carcinogenicity Results in CPDB on 1485 Chemicals. 2005
Review
Two of two studies report mammary tumors: Gass 1977 and Highman 1980.
http://potency.berkeley.edu/pdfs/ChemicalTable.pdf
Gass G, Allaben, WT. Preliminary report on the carcinogenic dose-response curve to oral vitamin D2. IRCS Med. Sci. 1977;Libr. Compen. 5:477.
Primary Literature
Highman B, Greenman DL, Norvell MJ, Farmer J, Shellenberger TE. Neoplastic and preneoplastic lesions induced in female C3H mice by diets containing diethylstilbestrol or 17 beta-estradiol. J Environ Pathol Toxicol 1980;4(5-6):81-95.
Primary Literature
National Toxicology Program 11th Report on Carcinogens, Table 1. Chemicals nominated to the National Toxicology Program for in-depth toxicological evaluation for carcinogenesis testing in fiscal years 1988-2003.
Review
Not nominated for NTP testing in 1998-2003.
http://ntp.niehs.nih.gov/ntp/roc/eleventh/tab1.pdf