Environment and Breast Cancer: Science Review
Cancer studies: Mammary gland tumors
The list(s) or database(s) in which the chemical was identified as showing an increase in mammary gland tumors. CPDB: Carcinogenic Potency Database, IARC: International Agency for Research on Chemicals Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man summaries, NTP TR: National Toxicology Program (NTP) Technical Reports, NTP 11ROC: NTP 11th Report on Carcinogens, CCRIS: Chemical Carcinogenesis Research Information Service.Carcinogenicity Potency Database, IARC Monographs, Chemical Carcinogenesis Research Information System
Mammary gland tumor summary
A summary of findings related to mammary gland tumors, most often excerpted from IARC Monographs or the NTP 11th ROC, and, in some cases, supplemented by our evaluation of individual studies and reviews, is available for the priority chemicals and 67 others.IARC 1983: When administered in the diet, produced benign and malignant mammary tumors in rats of both sexes.
Citations to review sources and individual studies reporting mammary gland tumors are listed below.
International Agency for Research on Cancer, Monographs on the evaluation of carcinogenic risk of chemicals to man.VOL.: 31 (1983) (p. 47) Af-2 [2-(2-furyl)-3-(5-nitro-2-furyl)acrylamide]. Summary of Data Reported and Evaluation.
Carcinogenic Potency Database 2005. Gold LS ST, Manley NB, Garfinkel GB, Ames BN. Summary Table by Chemical of Carcinogenicity Results in CPDB on 1485 Chemicals. 2005
Cohen SM, Ichikawa M, Bryan GT. Carcinogenicity of 2-(2-furyl)-3-(5-nitro-2-furyl)acrylamide (AF-2) fed to female Sprague-Dawley rats. Gann 1977;68(4):473-6.
Takayama S, Kuwabara N. Carcinogenic activity of 2-(2-furyl)-3-(5-nitro-2-furyl)-acrylamide, a food additive, in mice and rats. Cancer Lett 1977a;3(3-4):115-20.
Kinebuchi M, Kawachi T, Matsukura N, Sugimura T. Further studies on the carcinogenicity of a food additive, AF-2, in hamsters. Food Cosmet Toxicol 1979;17(4):339-41.
Miyaji T. Acute and chronic toxicity of furylfuramide in rats and mice. Tohoku J Exp Med 1971;103(4):331-69.
Sano T, Kawachi T, Matsukura N, Sasajima K, Sugimura T. Carcinogenicity of a food additive, AF-2, in hamsters and mice. Z Krebsforsch Klin Onkol Cancer Res Clin Oncol 1977;89(1):61-8.
Yokoro K, Kajihara H, Kodama Y, Nagao K, Hamada K, Kinomura A. Chronic toxicity of 2-(2-furyl)-3-(5-nitro-2-furyl) acrylamide (AF-2) in mice, with special reference to carcinogenicity in the forestomach. Gann 1977;68(6):825-8.
Takayama S, Kuwabara N. The production of skeletal muscle atrophy and mammary tumors in rats by feeding 2-(2-furyl)-3-(5-nitro-2-furyl)acrylamide. Toxicol Lett. 1977b;1:11-6.
National Toxicology Program 11th Report on Carcinogens, Table 1. Chemicals nominated to the National Toxicology Program for in-depth toxicological evaluation for carcinogenesis testing in fiscal years 1988-2003.