Environment and Breast Cancer: Science Review
AboutCancer studies: Mammary gland tumors
Originating list
The list(s) or database(s) in which the chemical was identified as showing an
increase in mammary gland tumors. CPDB: Carcinogenic Potency Database, IARC:
International Agency for Research on Chemicals Monographs on the Evaluation of
Carcinogenic Risk of Chemicals to Man summaries, NTP TR: National Toxicology Program
(NTP) Technical Reports, NTP 11ROC: NTP 11th Report on Carcinogens, CCRIS: Chemical
Carcinogenesis Research Information Service.
Carcinogenicity Potency Database, National Toxicology Program studies, IARC Monographs, Chemical Carcinogenesis Research Information System
Mammary gland tumor summary
A summary of findings related to mammary gland tumors, most
often excerpted from IARC Monographs or the NTP 11th ROC, and, in some cases,
supplemented by our evaluation of individual studies and reviews, is available for the priority
chemicals and 67 others.
NTP 11ROC: When administered by repeated intraperitoneal injection, procarbazine hydrochloride induced adenocarcinomas of the mammary gland in rats of both sexes. When administered by gavage, the compound induced adenocarcinomas or carcinomas of the mammary gland in female rats, but not in male rats.
Only review sources are listed for this chemical because of lower likelihood of exposure.
Citation
Source Type
Notes
International Agency for Research on Cancer, Monographs on the evaluation of carcinogenic risk of chemicals to man.VOL.: Supplement 7 (1987) (p. 327) Procarbazine Hydrochloride. Summary of Data Reported and Evaluation.
Review
National Toxicology Program 11th Report on Carcinogens. Procarbazine Hydrochloride.
Review
National Toxicology Program Technical Report 19, 1979
Primary Literature
National Toxicology Program 11th Report on Carcinogens, Table 1. Chemicals nominated to the National Toxicology Program for in-depth toxicological evaluation for carcinogenesis testing in fiscal years 1988-2003.
Review