Environment and Breast Cancer: Science Review
Cancer studies: Mammary gland tumors
The list(s) or database(s) in which the chemical was identified as showing an increase in mammary gland tumors. CPDB: Carcinogenic Potency Database, IARC: International Agency for Research on Chemicals Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man summaries, NTP TR: National Toxicology Program (NTP) Technical Reports, NTP 11ROC: NTP 11th Report on Carcinogens, CCRIS: Chemical Carcinogenesis Research Information Service.Carcinogenicity Potency Database, National Toxicology Program studies, IARC Monographs, Chemical Carcinogenesis Research Information System
Mammary gland tumor summary
A summary of findings related to mammary gland tumors, most often excerpted from IARC Monographs or the NTP 11th ROC, and, in some cases, supplemented by our evaluation of individual studies and reviews, is available for the priority chemicals and 67 others.An NTP study reported increased mammary tumors. A 'negative study' used lower exposure levels. NTP 11th ROC: Two year dietary studies in F344 rats showed significantly increased incidence of neoplasms of the mammary gland in males and females.
Citations to review sources and individual studies reporting mammary gland tumors are listed below.
International Agency for Research on Cancer, Monographs on the evaluation of carcinogenic risk of chemicals to man.VOL.: 77 (2000) (p. 455) 2,2-BIS(BROMOMETHYL)PROPANE-1,3-DIOL.
Carcinogenic Potency Database 2005. Gold LS ST, Manley NB, Garfinkel GB, Ames BN. Summary Table by Chemical of Carcinogenicity Results in CPDB on 1485 Chemicals. 2005
National Toxicology Program 11th Report on Carcinogens. 2,2-bis(Bromomethyl)-1,3- Propanediol (Technical Grade).
National Toxicology Program Technical Report 452, 1996
Keyes D, Kociba R, Schwetz R, Wade C, Dittenber D, Quinn T, et al. Results of a two-year toxicity and oncogenic study of rats ingesting diets containing dibromoneopentyl glycol (FR-1138). J. Combust. Toxicol. 1980;7:77-98.
Dunnick JK, Heath JE, Farnell DR, Prejean JD, Haseman JK, Elwell MR. Carcinogenic activity of the flame retardant, 2,2-bis(bromomethyl)-1,3-propanediol in rodents, and comparison with the carcinogenicity of other National Toxicology Program brominated chemicals. Toxicol Pathol 1997;25(6):541-8.