Environment and Breast Cancer: Science Review

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CAS RN 3296-90-0

Cancer studies: Mammary gland tumors
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Originating list
The list(s) or database(s) in which the chemical was identified as showing an increase in mammary gland tumors. CPDB: Carcinogenic Potency Database, IARC: International Agency for Research on Chemicals Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man summaries, NTP TR: National Toxicology Program (NTP) Technical Reports, NTP 11ROC: NTP 11th Report on Carcinogens, CCRIS: Chemical Carcinogenesis Research Information Service.
Carcinogenicity Potency Database, National Toxicology Program studies, IARC Monographs, Chemical Carcinogenesis Research Information System
Mammary gland tumor summary
A summary of findings related to mammary gland tumors, most often excerpted from IARC Monographs or the NTP 11th ROC, and, in some cases, supplemented by our evaluation of individual studies and reviews, is available for the priority chemicals and 67 others.
An NTP study reported increased mammary tumors. A 'negative study' used lower exposure levels. NTP 11th ROC: Two year dietary studies in F344 rats showed significantly increased incidence of neoplasms of the mammary gland in males and females.
Citations to review sources and individual studies reporting mammary gland tumors are listed below.
Source Type
International Agency for Research on Cancer, Monographs on the evaluation of carcinogenic risk of chemicals to man.VOL.: 77 (2000) (p. 455) 2,2-BIS(BROMOMETHYL)PROPANE-1,3-DIOL.
Mammary tumors increase in male and female rats in oral administration in diet studies: NTP TR452 1996 and Dunnick 1997.
Carcinogenic Potency Database 2005. Gold LS ST, Manley NB, Garfinkel GB, Ames BN. Summary Table by Chemical of Carcinogenicity Results in CPDB on 1485 Chemicals. 2005
One (NTP TR 452) of two studies had mammary tumors. Keyes did not show mammary tumors.
National Toxicology Program 11th Report on Carcinogens. 2,2-bis(Bromomethyl)-1,3- Propanediol (Technical Grade).
"Two year dietary studies of BBMP in F344 rats showed significantly increased incidences of neoplasms of the skin, subcutaneous tissue, mammary gland, Zymbal gland, oral cavity, esophagus, forestomach, small and large intestines, mesothelium, urinary bladder, lung, thyroid gland, and seminal vesicle and in the incidence of mononuclear cell leukemia in males, and an increase in the incidence of neoplasms of the oral cavity, esophagus, mammary gland, and thyroid gland in females."
National Toxicology Program Technical Report 452, 1996
Primary Literature

experimental details
Increased benign mammary tumors in male and female rats. Increased malignant mammary tumors in female mice. Rats: 0, 2500, 5000, 10,000 ppm in feed for 104-105 wks. male rats: 0/51, 4/53, 7/51, 7/55 fibroadenoma or adenoma female rats: 25/50, 45/51, 46/53, 45/52 fibroadenoma Mice: 0, 312, 625, 1250 ppm in feed for 104-105 wks female mice: 0/52, 0/50, 1/51, 3/50 carcinoma
Keyes D, Kociba R, Schwetz R, Wade C, Dittenber D, Quinn T, et al. Results of a two-year toxicity and oncogenic study of rats ingesting diets containing dibromoneopentyl glycol (FR-1138). J. Combust. Toxicol. 1980;7:77-98.
Primary Literature

experimental details
A study listed by CPDB 2005 that did not report mammary tumors. Mammary tumors in dosed animals were not significantly different from controls, though slight increase. Used levels lower than NTP TR452. Detected bromide in tissues in highest dosed group similar to the serum levels.
Dunnick JK, Heath JE, Farnell DR, Prejean JD, Haseman JK, Elwell MR. Carcinogenic activity of the flame retardant, 2,2-bis(bromomethyl)-1,3-propanediol in rodents, and comparison with the carcinogenicity of other National Toxicology Program brominated chemicals. Toxicol Pathol 1997;25(6):541-8.
Primary Literature
From IARC, review postponed.