Environment and Breast Cancer: Science Review

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Key References
Abbreviations
 

hydrazine
CAS RN 302-01-2

Chemical Summary
Exposure and Risk Assessment
Cancer Studies
 


Cancer studies: Mammary gland tumors
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Originating list
The list(s) or database(s) in which the chemical was identified as showing an increase in mammary gland tumors. CPDB: Carcinogenic Potency Database, IARC: International Agency for Research on Chemicals Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man summaries, NTP TR: National Toxicology Program (NTP) Technical Reports, NTP 11ROC: NTP 11th Report on Carcinogens, CCRIS: Chemical Carcinogenesis Research Information Service.
IARC Monographs
Mammary gland tumor summary
A summary of findings related to mammary gland tumors, most often excerpted from IARC Monographs or the NTP 11th ROC, and, in some cases, supplemented by our evaluation of individual studies and reviews, is available for the priority chemicals and 67 others.
Very limited evidence of mammary gland tumors.
Citations to review sources and individual studies reporting mammary gland tumors are listed below.
Citation
Source Type
Notes
International Agency for Research on Cancer, Monographs on the evaluation of carcinogenic risk of chemicals to man. Suppl 7 (1987) (p. 223) Hydrazine.
Review
Increased mammary tumors in mice by oral administration; Menon 1983.
http://monographs.iarc.fr/ENG/Monographs/suppl7/suppl7.pd...
International Agency for Research on Cancer, Monographs on the evaluation of carcinogenic risk of chemicals to man. VOL.: 71 (1999) (p. 991)
Review
"by oral administration to mice in several experiments, producing mammary and lung tumours.": IARC 1987 (vol.4) From IARC v4, 1971 "reduced the incidence of mammary tumours from 77% in the controls to 38% in the treated mice": Toth, 1969
http://monographs.iarc.fr/ENG/Monographs/vol71/volume71.p...
Carcinogenic Potency Database 2005. Gold LS ST, Manley NB, Garfinkel GB, Ames BN. Summary Table by Chemical of Carcinogenicity Results in CPDB on 1485 Chemicals. 2005
Review
One of five studies reported mammary tumors (though only at low dose of treatment): Steinhoff 1988. Studies that did not report mammary tumors: Vernot 1985, Steinhoff 1990, Roe 1967, Toth 1972/1969.
http://potency.berkeley.edu/pdfs/ChemicalTable.pdfpotency...
Roe FJ, Grant GA, Millican DM. Carcinogenicity of hydrazine and 1,1-dimethylhydrazine for mouse lung. Nature 1967;216(113):375-6.
Primary Literature
A study listed by CPDB 2005 that did not report mammary tumors. Pubmed did not have the abstract, but the title indicates that lung tumors were the sole endpoint and mammary tumors that may have occurred are unlikely to have been reported.
Steinhoff D, Mohr U, Schmidt WM. On the question of the carcinogenic action of hydrazine--evaluation on the basis of new experimental results. Exp Pathol 1990;39(1):1-9.
Primary Literature

experimental details
A study listed by CPDB 2005 that did not report mammary tumors.
Toth B. Hydrazine, methylhydrazine and methylhydrazine sulfate carcinogenesis in Swiss mice. Failure of ammonium hydroxide to interfere in the development of tumors. Int J Cancer 1972;9(1):109-18.
Primary Literature

experimental details
A study listed by CPDB 2005 that did not report mammary tumors.
Vernot EH, MacEwen JD, Bruner RH, Haun CC, Kinkead ER, Prentice DE, et al. Long-term inhalation toxicity of hydrazine. Fundam Appl Toxicol 1985;5(6 Pt 1):1050-64.
Primary Literature
A study listed by CPDB 2005 that did not report mammary tumors. Studied rats, mice, hamsters, and dogs with low inhalation exposures (up to 5 ppm) for one year with observation afterwards. Possible that exposure levels were too low to cause mammary tumors.
Steinhoff D, Mohr U. The question of carcinogenic effects of hydrazine. Exp Pathol 1988;33(3):133-43.
Primary Literature

experimental details
Menon MM, Bhide SV. Perinatal carcinogenicity of isoniazid (INH) in Swiss mice. J Cancer Res Clin Oncol 1983;105(3):258-61.
Primary Literature
From IARC, review postponed.
Toth B. Lung tumor induction and inhibition of breast adenocarcinomas by hydrazine sulfate in mice. J Natl Cancer Inst 1969;42(3):469-75.
Primary Literature
From IARC, review postponed.
National Toxicology Program 11th Report on Carcinogens, Table 1. Chemicals nominated to the National Toxicology Program for in-depth toxicological evaluation for carcinogenesis testing in fiscal years 1988-2003.
Review
Nominated for carcinogenicity testing by NASA, Lyndon B. Johnson Space Center 1991; under review. Rationale: - Shown to cause nasal tumors in rats and possibly lung adenomas in mice; however, the concentrations at which those effects were observed is quite uncertain. - Quality data lacking to set exposure levels for spacecraft as well as ground-based operations
http://ntp.niehs.nih.gov/ntp/roc/eleventh/tab1.pdf