Environment and Breast Cancer: Science Review

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Key References
Abbreviations
 

toluene diisocyanate mixtures
CAS RN 26471-62-5

Chemical Summary
Exposure and Risk Assessment
Cancer Studies
 


Cancer studies: Mammary gland tumors
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Originating list
The list(s) or database(s) in which the chemical was identified as showing an increase in mammary gland tumors. CPDB: Carcinogenic Potency Database, IARC: International Agency for Research on Chemicals Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man summaries, NTP TR: National Toxicology Program (NTP) Technical Reports, NTP 11ROC: NTP 11th Report on Carcinogens, CCRIS: Chemical Carcinogenesis Research Information Service.
Carcinogenicity Potency Database, IARC Monographs, National Toxicology Program studies, Chemical Carcinogenesis Research Information System
Mammary gland tumor summary
A summary of findings related to mammary gland tumors, most often excerpted from IARC Monographs or the NTP 11th ROC, and, in some cases, supplemented by our evaluation of individual studies and reviews, is available for the priority chemicals and 67 others.
NTP 11th ROC: When administered by gavage in corn oil, commercial-grade toluene diisocyanate (analyzed as 85% 2,4-isomer and 15% 2,6-isomer) induced mammary gland fibroadenomas in female rats.
Citations to review sources and individual studies reporting mammary gland tumors are listed below.
Citation
Source Type
Notes
International Agency for Research on Cancer, Monographs on the evaluation of carcinogenic risk of chemicals to man.VOL.: 39 (1986) (p. 302) Toluene Diisocyanates.
Review
IARC vo. 39: NTP TR 251, 1986 - the Working Group noted the poor survival rates of both male and female treated animals. Mammary tumors for study of NTP TR162, 1979: 2,4-Diaminotoluene (inluded in toluene diisocanate section): National Cancer Institute (1979) Bioassay of 2,4-Diaminotoluene for Possible Carcinogenicity.
http://monographs.iarc.fr/ENG/Monographs/vol39/volume39.p...
International Agency for Research on Cancer, Monographs on the evaluation of carcinogenic risk of chemicals to man.VOL.: 71 (1999) (p. 865) Toluene Diisocyanates.
Review
Administration by gavage induced an increase of mammary gland fibroadenomas in female rats. Refers to IARC v39
http://monographs.iarc.fr/ENG/Monographs/vol71/volume71.p...
Carcinogenic Potency Database 2005. Gold LS ST, Manley NB, Garfinkel GB, Ames BN. Summary Table by Chemical of Carcinogenicity Results in CPDB on 1485 Chemicals. 2005
Review
One of two studies reported mammary tumors: NTP TR251. One study did not report mammary tumors: Loeser 1983.
http://potency.berkeley.edu/pdfs/ChemicalTable.pdfpotency...
National Toxicology Program 11th Report on Carcinogens. Toluene Diisocyanates
Review
Administration by gavage in corn oil induced an increase of mammary gland fibroadenomas in female rats (NTP 1986).
http://ntp.niehs.nih.gov/ntp/roc/eleventh/profiles/s177td...
Loeser E. Long-term toxicity and carcinogenicity studies with 2,4/2,6-toluene-diisocyanate (80/20) in rats and mice. Toxicol Lett 1983;15(1):71-81.
Primary Literature
A study listed by CPDB 2005 that did not report mammary tumors.
National Toxicology Program Technical Report 162, 1979
Primary Literature
National Toxicology Program Technical Report 251, 1986
Primary Literature
http://ntp.niehs.nih.gov/ntp/htdocs/LT_rpts/tr251.pdf