Environment and Breast Cancer: Science Review
AboutCancer studies: Mammary gland tumors
Originating list
The list(s) or database(s) in which the chemical was identified as showing an
increase in mammary gland tumors. CPDB: Carcinogenic Potency Database, IARC:
International Agency for Research on Chemicals Monographs on the Evaluation of
Carcinogenic Risk of Chemicals to Man summaries, NTP TR: National Toxicology Program
(NTP) Technical Reports, NTP 11ROC: NTP 11th Report on Carcinogens, CCRIS: Chemical
Carcinogenesis Research Information Service.
Carcinogenicity Potency Database
Mammary gland tumor summary
A summary of findings related to mammary gland tumors, most
often excerpted from IARC Monographs or the NTP 11th ROC, and, in some cases,
supplemented by our evaluation of individual studies and reviews, is available for the priority
chemicals and 67 others.
Evidence of increased incidence of tumors at multiple sites including mammary gland in rats.
Citations to review sources and individual studies reporting mammary gland tumors are listed below.
Citation
Source Type
Notes
International Agency for Research on Cancer, Monographs on the evaluation of carcinogenic risk of chemicals to man.VOL.: 53 (1991) (p. 353) Captafol. Summary of Data Reported and Evaluation.
Review
Carcinogenic Potency Database 2005. Gold LS ST, Manley NB, Garfinkel GB, Ames BN. Summary Table by Chemical of Carcinogenicity Results in CPDB on 1485 Chemicals. 2005
Review
Quest JA, Fenner-Crisp PA, Burnam W, Copley M, Dearfield KL, Hamernik KL, et al. Evaluation of the carcinogenic potential of pesticides. 4. Chloroalkylthiodicarboximide compounds with fungicidal activity. Regul Toxicol Pharmacol 1993;17(1):19-34.
Primary Literature
Ito N, Ogiso T, Fukushima S, Shibata M, Hagiwara A. Carcinogenicity of captafol in B6C3F1 mice. Gann 1984;75(10):853-65.
Primary Literature
Nyska A, Waner T, Pirak M, Gordon E, Bracha P, Klein B. The renal carcinogenic effect of Merpafol in the Fischer 344 rat. Isr J Med Sci 1989;25(8):428-32.
Primary Literature
Tamano S, Kurata Y, Kawabe M, Yamamoto A, Hagiwara A, Cabral R, et al. Carcinogenicity of captafol in F344/DuCrj rats. Jpn J Cancer Res 1990;81(12):1222-31.
Primary Literature
National Toxicology Program 11th Report on Carcinogens, Table 1. Chemicals nominated to the National Toxicology Program for in-depth toxicological evaluation for carcinogenesis testing in fiscal years 1988-2003.
Review