Environment and Breast Cancer: Science Review
AboutCancer studies: Mammary gland tumors
Originating list
The list(s) or database(s) in which the chemical was identified as showing an
increase in mammary gland tumors. CPDB: Carcinogenic Potency Database, IARC:
International Agency for Research on Chemicals Monographs on the Evaluation of
Carcinogenic Risk of Chemicals to Man summaries, NTP TR: National Toxicology Program
(NTP) Technical Reports, NTP 11ROC: NTP 11th Report on Carcinogens, CCRIS: Chemical
Carcinogenesis Research Information Service.
Carcinogenicity Potency Database, IARC Monographs, National Toxicology Program 11th Report on Carcinogens, Chemical Carcinogenesis Research Information System
Mammary gland tumor summary
A summary of findings related to mammary gland tumors, most
often excerpted from IARC Monographs or the NTP 11th ROC, and, in some cases,
supplemented by our evaluation of individual studies and reviews, is available for the priority
chemicals and 67 others.
NTP 11th ROC: The evidence that dyes metabolized to benzidine are human carcinogens is supported by studies showing that all benzidine-based dyes tested cause cancer in experimental animals. C.I. direct black 38 administered in drinking water or in the diet caused malignant mammary-gland tumors in mice.
Citations to review sources and individual studies reporting mammary gland tumors are listed below.
Citation
Source Type
Notes
International Agency for Research on Cancer, Monographs on the evaluation of carcinogenic risk of chemicals to man.VOL.: 29 (1982) (p. 295) Direct Black 38 Summary of Data Reported and Evaluation.
Review
Carcinogenic Potency Database 2005. Gold LS ST, Manley NB, Garfinkel GB, Ames BN. Summary Table by Chemical of Carcinogenicity Results in CPDB on 1485 Chemicals. 2005
Review
National Toxicology Program 11th Report on Carcinogens. Benzidine and Dyes Metabolized to Benzidine
Review
Asada I, Matsumoto Y, Tobe T, Yoshida O, Miyakawa M. Induction of hepatoma in mice by direct deep Black-Extra (DDB-EX) and occurrence of serum AFP. Nippon Geka Hokan 1981;50(1):45-55.
Primary Literature
Niitsu K. Studies on the metabolism and carcinogenicity of azo dyes used for food colors and direct dyestuffs. Part II. Studies on the metabolism and carcinogenicity of direct dyestuffs bule BB and black EX (Jpn.). Tokyo Jikeikai Ika Daigaku Zasshi. 1973;88:467-71.
Primary Literature
National Toxicology Program 11th Report on Carcinogens, Table 1. Chemicals nominated to the National Toxicology Program for in-depth toxicological evaluation for carcinogenesis testing in fiscal years 1988-2003.
Review