Environment and Breast Cancer: Science Review

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CAS RN 1420-04-8

Cancer studies: Mammary gland tumors
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Originating list
The list(s) or database(s) in which the chemical was identified as showing an increase in mammary gland tumors. CPDB: Carcinogenic Potency Database, IARC: International Agency for Research on Chemicals Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man summaries, NTP TR: National Toxicology Program (NTP) Technical Reports, NTP 11ROC: NTP 11th Report on Carcinogens, CCRIS: Chemical Carcinogenesis Research Information Service.
National Toxicology Program studies
Mammary gland tumor summary
A summary of findings related to mammary gland tumors, most often excerpted from IARC Monographs or the NTP 11th ROC, and, in some cases, supplemented by our evaluation of individual studies and reviews, is available for the priority chemicals and 67 others.
An NTP study of clonitralid found increased mammary adenocarcinomas in male and female rats, however these findings were considered equivocal based on life-table analysis.
Citations to review sources and individual studies reporting mammary gland tumors are listed below.
Source Type
National Toxicology Program Technical Report 91, 1978
Primary Literature
Substantially increased mammary adenocarcinomas in female rats by ingestion. 1/20 (controls), 12/50 (mid), 11/50 (high) with much earlier time of onset in treated animals. Life-table analysis found this increase non-significant. Non-significant increase in mammary adenocarcinomas in treated male rats supports the finding in female rats.
National Toxicology Program 11th Report on Carcinogens, Table 1. Chemicals nominated to the National Toxicology Program for in-depth toxicological evaluation for carcinogenesis testing in fiscal years 1988-2003.
Not nominated for NTP testing in 1998-2003.