Environment and Breast Cancer: Science Review

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CAS RN 126-99-8

Cancer studies: Mammary gland tumors
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Originating list
The list(s) or database(s) in which the chemical was identified as showing an increase in mammary gland tumors. CPDB: Carcinogenic Potency Database, IARC: International Agency for Research on Chemicals Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man summaries, NTP TR: National Toxicology Program (NTP) Technical Reports, NTP 11ROC: NTP 11th Report on Carcinogens, CCRIS: Chemical Carcinogenesis Research Information Service.
Carcinogenicity Potency Database, IARC Monographs, National Toxicology Program studies, Chemical Carcinogenesis Research Information System
Mammary gland tumor summary
A summary of findings related to mammary gland tumors, most often excerpted from IARC Monographs or the NTP 11th ROC, and, in some cases, supplemented by our evaluation of individual studies and reviews, is available for the priority chemicals and 67 others.
NTP 11th ROC: Inhalation exposure of rats and mice to chloroprene vapors induced increased incidence of neoplasms of the mammary gland in females of both species.
Citations to review sources and individual studies reporting mammary gland tumors are listed below.
Source Type
International Agency for Research on Cancer, Monographs on the evaluation of carcinogenic risk of chemicals to man.VOL.: 71 (1999) (p. 227) Chloroprene.
In one study in mice and rats exposed by inhalation, mammary gland tumors were increased: NTP TR 467, 1998. In another study in a different strain of rats, the incidence of mammary tumors was increased in high-dose females only when mammary tumors of all types were combined: Trochimowicz 1998.
Carcinogenic Potency Database 2005. Gold LS ST, Manley NB, Garfinkel GB, Ames BN. Summary Table by Chemical of Carcinogenicity Results in CPDB on 1485 Chemicals. 2005
One of one study reports mammary tumors: NTP TR467.
National Toxicology Program 11th Report on Carcinogens. Chloroprene
After exposure by inhalation, increased incidences of neoplasms of the mammary gland in female rats and female mice (NTP 1998).
National Toxicology Program Technical Report 467, 1998
Primary Literature
Trochimowicz H, Loser E, Feron V, Clary J, Valentine R. Chronic inhalation toxicity and carcinogenicity studies of B-chloroprene in rats and hamsters. Inhal. Toxicol 1998;10(5):443-472.
Primary Literature
From IARC, review postponed.