Environment and Breast Cancer: Science Review
AboutCancer studies: Mammary gland tumors
Originating list
The list(s) or database(s) in which the chemical was identified as showing an
increase in mammary gland tumors. CPDB: Carcinogenic Potency Database, IARC:
International Agency for Research on Chemicals Monographs on the Evaluation of
Carcinogenic Risk of Chemicals to Man summaries, NTP TR: National Toxicology Program
(NTP) Technical Reports, NTP 11ROC: NTP 11th Report on Carcinogens, CCRIS: Chemical
Carcinogenesis Research Information Service.
Carcinogenicity Potency Database, IARC Monographs, Chemical Carcinogenesis Research Information System
Mammary gland tumor summary
A summary of findings related to mammary gland tumors, most
often excerpted from IARC Monographs or the NTP 11th ROC, and, in some cases,
supplemented by our evaluation of individual studies and reviews, is available for the priority
chemicals and 67 others.
IARC 1999: When administered orally, produced an increased incidence of mammary gland tumors in rats. An NTP study of 1,4-dioxane did not find mammary gland tumors.
Citations to review sources and individual studies reporting mammary gland tumors are listed below.
Citation
Source Type
Notes
International Agency for Research on Cancer, Monographs on the evaluation of carcinogenic risk of chemicals to man.VOL.: 71 (1999) (p. 589) 1,4-Dioxane. Summary of Data Reported and Evaluation.
Review
Carcinogenic Potency Database 2005. Gold LS ST, Manley NB, Garfinkel GB, Ames BN. Summary Table by Chemical of Carcinogenicity Results in CPDB on 1485 Chemicals. 2005
Review
National Toxicology Program 11th Report on Carcinogens. 1,4-Dioxane
Review
Yamazaki K, Ohno H, Asakura M, Narumi A, Ohbayashi H, Fujita H, et al. Two-year toxicological and carcinogenesis studies of 1,4-dioxane in F344 rats and BDF1 mice. Drinking studies. Proc. Int. Center Med. Res. Seminar 1994;1993:193-198.
Primary Literature
Argus MF, Arcos JC, Hochligeti C. Studies on the carcinogenic activity of protein-denaturing agents: hepatocarcinogenicity of dioxane. J Natl Cancer Inst 1965;35(6):949-58.
Primary Literature
Hoch-Ligeti C, Argus MF, Arcos JC. Induction of carcinomas in the nasal cavity of rats by dioxane. Br J Cancer 1970;24(1):164-7.
Primary Literature
Kociba R, McCollister S, Park C, Torkelson T, Gehring P. 1,4-Dioxane. 1. Results of a 2-year ingestion study in rats. Toxicol. Appl. Pharmacol. 1974;30:275-286.
Primary Literature
National Toxicology Program Technical Report 80, 1978
National Toxicology Program 11th Report on Carcinogens, Table 1. Chemicals nominated to the National Toxicology Program for in-depth toxicological evaluation for carcinogenesis testing in fiscal years 1988-2003.
Review