Environment and Breast Cancer: Science Review

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Key References
Abbreviations
 

hydrazobenzene
CAS RN 122-66-7

Chemical Summary
Exposure and Risk Assessment
Cancer Studies
 


Cancer studies: Mammary gland tumors
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Originating list
The list(s) or database(s) in which the chemical was identified as showing an increase in mammary gland tumors. CPDB: Carcinogenic Potency Database, IARC: International Agency for Research on Chemicals Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man summaries, NTP TR: National Toxicology Program (NTP) Technical Reports, NTP 11ROC: NTP 11th Report on Carcinogens, CCRIS: Chemical Carcinogenesis Research Information Service.
Carcinogenicity Potency Database, National Toxicology Program studies
Mammary gland tumor summary
A summary of findings related to mammary gland tumors, most often excerpted from IARC Monographs or the NTP 11th ROC, and, in some cases, supplemented by our evaluation of individual studies and reviews, is available for the priority chemicals and 67 others.
NTP 11ROC: When administered in the diet, hydrazobenzene induced mammary adenomas in female rats. When injected subcutaneously in sunflower seed oil, hydrazobenzene induced mammary microfollicular carcinomas.
Only review sources are listed for this chemical because of lower likelihood of exposure.
Citation
Source Type
Notes
Carcinogenic Potency Database 2005. Gold LS ST, Manley NB, Garfinkel GB, Ames BN. Summary Table by Chemical of Carcinogenicity Results in CPDB on 1485 Chemicals. 2005
Review
One of one study (NTP TR92) reports mammary tumors.
http://potency.berkeley.edu/pdfs/ChemicalTable.pdfpotency...
National Toxicology Program 11th Report on Carcinogens. Hydrazobenzene
Review
Reports on NTP TR92 results and a positive? @@ subcutaneous study that is not well cited, possibly the Russian study Pliss 1974 (abstract not available). Pliss, G. B. 1974. [Carcinogenic properties of hydrazobenzene]. Vopr Onkol 20(4): 53-7.
http://ntp.niehs.nih.gov/ntp/roc/eleventh/profiles/s097hy...
National Toxicology Program Technical Report 92, 1978
Primary Literature

experimental details
Increased malignant mammary tumors in female rats. Rat, female: 0, 0.004%, 0.01% of feed for 78 wks. 1/98, 3/50, 6/50 T+ adenocarcinoma
http://ntp.niehs.nih.gov/ntp/htdocs/LT_rpts/tr092.pdf