Environment and Breast Cancer: Science Review

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CAS RN 121-66-4

Cancer studies: Mammary gland tumors
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Originating list
The list(s) or database(s) in which the chemical was identified as showing an increase in mammary gland tumors. CPDB: Carcinogenic Potency Database, IARC: International Agency for Research on Chemicals Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man summaries, NTP TR: National Toxicology Program (NTP) Technical Reports, NTP 11ROC: NTP 11th Report on Carcinogens, CCRIS: Chemical Carcinogenesis Research Information Service.
Carcinogenicity Potency Database, IARC Monographs
Mammary gland tumor summary
A summary of findings related to mammary gland tumors, most often excerpted from IARC Monographs or the NTP 11th ROC, and, in some cases, supplemented by our evaluation of individual studies and reviews, is available for the priority chemicals and 67 others.
IARC 1983: In one experiment in female rats,2-amino-5-nitrothiazole increased the incidence of benign mammary tumors. An NTP study of 2-amino-5-nitrothiazole did not find mammary gland tumors.
Citations to review sources and individual studies reporting mammary gland tumors are listed below.
Source Type
International Agency for Research on Cancer, Monographs on the evaluation of carcinogenic risk of chemicals to man.VOL.: 31 (1983) (p. 71) 2-amino-5-nitrothiazole. Summary of Data Reported and Evaluation.
Administration by diet induced mammary tumors in female rats. [The Working Group noted the short duration of this experiment]: Cohen 1975.
Carcinogenic Potency Database 2005. Gold LS ST, Manley NB, Garfinkel GB, Ames BN. Summary Table by Chemical of Carcinogenicity Results in CPDB on 1485 Chemicals. 2005
One of two studies report mammary tumors: Cohen 1975. One study did not report mammary tumors: NTP TR53.
Cohen S, Erturk E, Von Esch A, Corvetti A, Bryan G. Carcinogenicity of 5-nitrofurans and related compounds with amino-heterocyclic substituents. J Natl Cancer Inst. 1975 Apr;54(4):841-50.
Primary Literature
National Toxicology Program Technical Report 53, 1978
Primary Literature
National Toxicology Program 11th Report on Carcinogens, Table 1. Chemicals nominated to the National Toxicology Program for in-depth toxicological evaluation for carcinogenesis testing in fiscal years 1988-2003.
Not nominated for NTP testing in 1998-2003.