Environment and Breast Cancer: Science Review

Evidence From Humans
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Green tea intake, ACE gene polymorphism and breast cancer risk among Chinese women in Singapore
Yuan, J.M., Koh, W.P., Sun, C.L., Lee, H.P., Yu, M.C. Carcinogenesis. 2005. March, .
Topic area
Diet - Genetic Variability
Study design
Nested case-control study
Study Participants
Menopausal Status
The menopausal status of women included in this study is listed here.
Pre menopausal
Post menopausal
Number of Controls
Participant selection: Inclusion and exclusion criteria
Criteria used to select participants in the study.
Incident breast cancer cases identified from Singapore population-based cancer registry, with confirmed histological and staging information and in the Singapore Chinese Health Study. Cancer free cohort members were matched to cases.
Exposures investigated
FFQ for dietary risk factors, allele frequencies of ACE, used TaqMan assay
How exposure was measured
Biological Questionnaire, in person
Statistical Analysis
Ethnic groups with separate analysis
If this study provided a separate analysis by ethnic or racial group, the groups are listed here.
Yes: Cantonese and Hokkien dialect subgroups
Confounders considered
Other breast cancer risk factors, such as family history, age at first birth, and hormone replacement therapy use, that were taken into account in the study.
Difficult to determine if BMI and family history were considered
Genetic characterization included
If the study analyzed relationships between environmental factors and inherited genetic variations, this field will be marked “Yes.” “No”, if not.
Description of major analysis
Logistic regression analysis of ACE genotype and green tea consumption, including interactions
Strength of associations reported
>= weekly drinker among high activity genotype: OR=0.29 (0.10-0.79)
>=weekly drinker among low activity genotype: OR=1.11 (0.79-1.57)
Significant interaction term (p=0.01) between genotype and green tea consumption
Results Comments
Difficult to assess menopausal status as possible effect modifier