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Anthropometry, breast cancer and menopausal status: use of repeated measurements over 10 years of follow-up-results of the French E3N women's cohort study
Tehard, B., Lahmann, P. H., Riboli, E., Clavel-Chapelon, F. International Journal of Cancer. 2004. 111:2, 264-9.
Topic area
Body size
Study design
Prospective cohort
Funding agency
Other: French League against Cancer, European Comm
Link to Abstract
Study Participants
Number of Cases
2,308, invasive only (786 premenopausal) (1,522 postmenopausal)
Menopausal Status
The menopausal status of women included in this study is listed here.
Post menopausal
Pre menopausal
Number in Cohort
Cohort: 94,805
Country where study was conducted
France
Cohort participation rate
Retention/participation exceeded 70% for exposed a
Participant selection: Inclusion and exclusion criteria
Criteria used to select participants in the study.
In: Age at baseline 40-65 yrs, lived in France at baseline, participant in E3N Cohort (EPIC) Ex: Women with undefined menopausal status, women who have never menstruated, women with other cancer at enrollment
Comment about participation selection
Strengths: first cohort to consider weight and BMI as time-dependent variables with data updated every 24 months, large cohort size, small validation study of self reported exposures Limitations: Women in cohort under-represented obese women, anthropometric measurements were self-reported
Exposure Investigated
Exposures investigated
Weight, BMI,
How exposure was measured
Questionnaire, self-administered
Exposure assessment comment
Self administered questionnaire regarding body size
Early life exposures considered
None
Breast cancer outcome investigated
Primary breast cancer
Ethnic groups with separate analysis
If this study provided a separate analysis by ethnic or racial group, the groups are listed here.
No
Confounders considered
Other breast cancer risk factors, such as family history, age at first birth, and hormone replacement therapy use, that were taken into account in the study.
Adequately controlled, Confounders: age at menarche, age at first birth, history of breast cancer, history of benign breast disease, alcohol, education, marital status, physical activity and height
Genetic characterization included
If the study analyzed relationships between environmental factors and inherited genetic variations, this field will be marked “Yes.” “No”, if not.
No
Description of major analysis
Mean follow up: 9.7 yrs Effect modifiers: menopausal status, HRT use
Strength of associations reported
Association between premenopausal breast cancer risk and weight, >63 kg vs. <52 kg, RR=0.75(0.61-0.93)
Association between postmenopausal breast cancer risk and weight, >68 kg vs. <53 kg, RR=1.10(0.93-1.29)
Association between postmenopausal breast cancer risk and weight, continuous per 2 unit increase, RR=1.05(1.02-1.08)
Association between premenopausal breast cancer risk and BMI, >23.4 vs. <20.2, RR=0.78(0.64-0.94)
Association between postmenopausal breast cancer risk and BMI, >26.2 kg vs. <20.6 kg, RR=1.15(1.00-1.34)
Association between postmenopausal breast cancer risk and BMI, continuous, RR=1.06(1.02-1.09)
Association between postmenopausal breast cancer risk and BMI in HRT users, >24.2 vs. <20.6 kg, RR=1.26(1.04-1.54)
Association between postmenopausal breast cancer risk and BMI in non-HRT users, >24.2 vs. <20.6 kg, RR=0.90(0.75-1.09)
Author address
Equipe E3N-IGR, INSERM XR 521, Institut Gustave Roussy, Villejuif, France.