Environment and Breast Cancer: Science Review

Evidence From Humans
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Reduced DNA repair of benzo[a]pyrene diol epoxide-induced adducts and common XPD polymorphisms in breast cancer patients
Shi, Q., Wang, L. E., Bondy, M. L., Brewster, A., Singletary, S. E., Wei, Q. Carcinogenesis. 2004. 25:9, 1695-700.
Topic area
Environmental pollutant - PAH
Study design
Hospital based case-control
Study Participants
Participant selection: Inclusion and exclusion criteria
Criteria used to select participants in the study.
Patients with newly diagnosed breast cancer and cancer-free controls
Exposures investigated
PAH-DNA adducts in peripheral blood lymphocytes, XPD
Ethnic groups with separate analysis
If this study provided a separate analysis by ethnic or racial group, the groups are listed here.
Confounders considered
Other breast cancer risk factors, such as family history, age at first birth, and hormone replacement therapy use, that were taken into account in the study.
Adequately controlled
Genetic characterization included
If the study analyzed relationships between environmental factors and inherited genetic variations, this field will be marked “Yes.” “No”, if not.
Strength of associations reported
Benzo[a]pyrene diol epoxide-induced DNA damage was associated with increased risk of breast cancer, especially in subgroups under 45 years of age. Results are statistically unstable due to small sample size.
Results Comments
XPD polymorphisms affect nucleotide excision DNA repair
Author address
Department of Epidemiology, The University of Texas M. D. Anderson Cancer Center, Houston, TX 77030, USA.