Environment and Breast Cancer: Science Review

Evidence From Humans
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Biomarkers of dietary fatty acid intake and the risk of breast cancer: a meta-analysis
Saadatian-Elahi, M., Norat, T., Goudable, J., Riboli, E. Int J Cancer. 2004. 111:4, 584-91.
Study design
Meta-analysis of nested case-control
Funding agency
Not reported
Study Participants
Menopausal Status
The menopausal status of women included in this study is listed here.
Post menopausal and premenopausal combined
Number of Controls
Controls: 728
Participant selection: Inclusion and exclusion criteria
Criteria used to select participants in the study.
Studies that published relative risks estimates and confidence intervals
Comment about participation selection
Heterogeneity of methodology
Exposure Investigated
Exposures investigated
Fatty acids: total saturated fatty acids (SFA), total monounsaturated fatty acids (MUFA), total n-6 polyunsaturated fatty acids (n-6 PUFA), linoleic acid, total n-3 polyunsaturated fatty acids (n-3 PUFA)
Exposure assessment comment
No information on biomarkers measures and follow-up of each study
Statistical Analysis
Ethnic groups with separate analysis
If this study provided a separate analysis by ethnic or racial group, the groups are listed here.
Confounders considered
Other breast cancer risk factors, such as family history, age at first birth, and hormone replacement therapy use, that were taken into account in the study.
Not reported
Genetic characterization included
If the study analyzed relationships between environmental factors and inherited genetic variations, this field will be marked “Yes.” “No”, if not.
Description of major analysis
Pooled RR with 95% CI, average of the RR estimated from the highest category of fatty acids from all studies versus lowest
Strength of associations reported
SFA: 1.36 (0.84-2.19); MUFA: 1.93 (1.03-3.61), n-6 PUFA: 0.67 (0.44-1.02) , linoleic acid: 0.91 (0.53-1.57), n-3 PUFA: 0.61 (0.40-0.93)
Results Comments
A significant protective effect was found for n-3 PUFA, while total MUFA were significantly associated with an increase risk.
Author address
International Agency for Research on Cancer, Lyon, France. saadatian@iarc.fr