Environment and Breast Cancer: Science Review

Evidence From Humans
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High fat and alcohol intakes are risk factors of postmenopausal breast cancer: a prospective study from the Malmo diet and cancer cohort
Mattisson, I., Wirfalt, E., Wallstrom, P., Gullberg, B., Olsson, H., Berglund, G. Int J Cancer. 2004. 110:4, 589-97.
Topic area
Diet - Alcohol
Study design
Prospective cohort
Funding agency
Other: Swedish cancer society, Swedish Medical Cou
Study Participants
Menopausal Status
The menopausal status of women included in this study is listed here.
Post menopausal
Number in Cohort
Cohort 11,726
Participant selection: Inclusion and exclusion criteria
Criteria used to select participants in the study.
In: Women of the MDC cohort 50 years or older at baseline examination, living in the city of Malmo, Sweden. Ex: Women with inadequate Swedish language, mental incapacity, prevalent cancer except cervical cancer in situ and nonmalignant melanoma skin cancer at baseline.
Exposure Investigated
How exposure was measured
Questionnaire, in person, FFQ Questionnaire, self-administered, 7 days registration
Exposure assessment comment
Lack of information about food items on the questionnaires
Statistical Analysis
Ethnic groups with separate analysis
If this study provided a separate analysis by ethnic or racial group, the groups are listed here.
Confounders considered
Other breast cancer risk factors, such as family history, age at first birth, and hormone replacement therapy use, that were taken into account in the study.
Not considered: BMI, family history of breast cancer, race, parity
Genetic characterization included
If the study analyzed relationships between environmental factors and inherited genetic variations, this field will be marked “Yes.” “No”, if not.
Description of major analysis
Adjusted IRR with 95% CI, fat intake analyzed as a variable regressed on total energy (FATTE) in quintiles, higher versus lower quintile, follow-up 7.6 years
Results Comments
Positive trend in risk of breast cancer across total fat intake quintiles.
Author address
Department of Medicine, Surgery and Orthopedics, Lund University, Malmo, Sweden. irene.mattisson@smi.mas.lu.se