Environment and Breast Cancer: Science Review

Evidence From Humans
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Birth weight is associated with postmenopausal breast cancer risk in Swedish women
Lahmann, P. H., Gullberg, B., Olsson, H., Boeing, H., Berglund, G., Lissner, L. Br J Cancer. 2004. 91:9, 1666-8.
Topic area
Early life exposures
Study design
Nested case-control
Funding agency
Other: Swedish Cancer Society, Swedish Medical Res
Study Participants
Menopausal Status
The menopausal status of women included in this study is listed here.
Number in Cohort
Controls: 238 Cohort: 5313
Participant selection: Inclusion and exclusion criteria
Criteria used to select participants in the study.
Malmo Diet and Cancer Study (EPIC) In: women born from singleton birth in Malmo between 1924 and 1950 with available birth record, cases: aged more than 55 years at breast cancer diagnosis, controls were aged matched without history of breast cancer
How exposure was measured
Other: Birth records
Statistical Analysis
Breast cancer outcome investigated
Primary incident breast cancer
Ethnic groups with separate analysis
If this study provided a separate analysis by ethnic or racial group, the groups are listed here.
Confounders considered
Other breast cancer risk factors, such as family history, age at first birth, and hormone replacement therapy use, that were taken into account in the study.
Race, parity, alcohol consumption, family history of breast cancer
Genetic characterization included
If the study analyzed relationships between environmental factors and inherited genetic variations, this field will be marked “Yes.” “No”, if not.
Description of major analysis
Conditional logistic regression coditioned on age, and additionally adjusted for birth year, maternal hypertension/proteinuria, parental occupation, adult BMI, and educational attainment. Adjusted OR with 95% CI, categorical variable: >=4000g versus < 300
Results Comments
Increase birth weight was associated with increased risk of postmenopausal breast cancer
Author address
Department of Epidemiology, German Institute of Human Nutrition Potsdam-Rehbrucke, Arthur-Scheunert-Allee 114-116, 14558 Nuthetal, Germany. lahmann@mail.dife.de