Environment and Breast Cancer: Science Review

Evidence From Humans
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The CYP19 gene codon 39 Trp/Arg polymorphism increases breast cancer risk in subsets of premenopausal Japanese
Hirose, K., Matsuo, K., Toyama, T., Iwata, H., Hamajima, N., Tajima, K. Cancer Epidemiology, Biomarkers and Prevention. 2004. 13:8, 1407-11.
Topic area
Body size - Genetic variability
Study design
Hospital based case-control study
Funding agency
Japanese Ministry of Health, Labor, and Welfare; J
Study Participants
Menopausal Status
The menopausal status of women included in this study is listed here.
Pre menopausal
Post menopausal
Participant selection: Inclusion and exclusion criteria
Criteria used to select participants in the study.
Participants of the Hospital-Based Epidemiologic Research Program at Aichi Cancer Center. Histologically confirmed cases referred to Department of Breast Surgery in Aichi Cancer Center Hospital. Controls were first visit outpatients to Department of Breast surgery with no diagnosis of cancer
Comment about participation selection
Although hospital controls may be different from general population, authors suggest that first time hospital visits are similar to first time clinical visits in US Sample did not meet expected gene frequencies based on Hardy-Weinberg
Exposures investigated
BMI, CYP19 allele frequencies, used PCR-RFLP
How exposure was measured
Biological Questionnaire, self-administered
Ethnic groups with separate analysis
If this study provided a separate analysis by ethnic or racial group, the groups are listed here.
Confounders considered
Other breast cancer risk factors, such as family history, age at first birth, and hormone replacement therapy use, that were taken into account in the study.
Adequately controlled
Genetic characterization included
If the study analyzed relationships between environmental factors and inherited genetic variations, this field will be marked “Yes.” “No”, if not.
Description of major analysis
Logistic regression analysis of CYP19 genotype and breast cancer, including effect modification by BMI
Strength of associations reported
Age–adjusted OR for TC/CC genotypes (compared to TT) was 1.21 (CI: 0.69-2.14)
BMI-stratified analyses showed OR=2.77 (CI:1.12-6.87) for premenopausal women with BMI >= 21·
Post-menopausal women with at least one C allele and BMI >= 24 showed OR=0.74 (CI: 0.18-3.03)