Environment and Breast Cancer: Science Review

Evidence From Humans
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Effects of ambient particulate matter on human breast cancer: is xenogenesis responsible?
Huo, Q., Zhang, N., Wang, X., Jiang, L., Ma, T., Yang, Q. PLoS One. 2013. 8:10, e76609.
Topic area
Environmental pollutant - Air pollution Vehicle Exhaust
Study design
Hospital-based case-only
Funding agency
National Natural Science Foundation of China Shand
Study Participants
Menopausal Status
The menopausal status of women included in this study is listed here.
No analyses based on menopausal status
Participant selection: Inclusion and exclusion criteria
Criteria used to select participants in the study.
Cases included women recruited from Qilu Hospital who were diagnosed with invasive breast cancer or ductal carcinoma in situ between 2001 and 2006. Breast cancer was confirmed by surgery, and pathological examinations were conducted for each participant. Only long-term residents of the Shandong Province who resided in the same city for at least 10 years prior to their diagnosis were included. Patients whose review information was inconsistent with their medical records were excluded.
Exposures investigated
City-level PM10 concentrations from the Environmental Protection Bureau within the Shandong Province from 2001-2006, assigned to residence at diagnosis and classified as low, medium, or high based on information about annual and daily averages. Cases livi
How exposure was measured
GIS/geographic location
Breast cancer outcome investigated
Primary incident breast cancer
Confounders considered
Other breast cancer risk factors, such as family history, age at first birth, and hormone replacement therapy use, that were taken into account in the study.
Age and smoking status
Genetic characterization included
If the study analyzed relationships between environmental factors and inherited genetic variations, this field will be marked “Yes.” “No”, if not.
Strength of associations reported
High PM10 vs. low PM10 among all female BC cases:
ER+ vs ER-: OR 1.58 (95% CI 1.07-2.32)
PR+ vs PR-: OR 0.91 (95% CI 0.60-1.39)
Invasive vs. DCIS: OR 1.71 (95% CI 1.06-2.76)
Histologic grade 2 or 3 vs 1: OR 2.24 (95% CI 1.09-4.59)
Results Comments
High vs low PM10 was associated with significantly elevated odds of having a family history of breast cancer (OR = 4.67; 95% CI: 1.12-19.38).
Author address
Department of Breast Surgery, Qilu Hospital of Shandong University, Shandong, China ; School of Medicine, Shandong University, Shandong, China.